TY - JOUR
T1 - Cannabinoids modulate the P-type high-voltage-activated calcium currents in Purkinje neurons
AU - Fisyunov, A.
AU - Tsintsadze, V.
AU - Min, R.
AU - Burnashev, N.
AU - Lozovaya, N.
PY - 2006
Y1 - 2006
N2 - Endocannabinoids released by postsynaptic cells inhibit neurotransmitter release in many central synapses by activating presynaptic cannabinoid CB1 receptors. In particular, in the cerebellum, endocannabinoids inhibit synaptic transmission at granule cell to Purkinje cell synapses by modulating presynaptic calcium influx via N-, P/Q-, and R-type calcium channels. Using whole cell patch-clamp techniques, we show that in addition to this presynaptic action, both synthetic and endogenous cannabinoids inhibit P-type calcium currents in isolated rat Purkinje neurons independent of CB1 receptor activation. The IC
AB - Endocannabinoids released by postsynaptic cells inhibit neurotransmitter release in many central synapses by activating presynaptic cannabinoid CB1 receptors. In particular, in the cerebellum, endocannabinoids inhibit synaptic transmission at granule cell to Purkinje cell synapses by modulating presynaptic calcium influx via N-, P/Q-, and R-type calcium channels. Using whole cell patch-clamp techniques, we show that in addition to this presynaptic action, both synthetic and endogenous cannabinoids inhibit P-type calcium currents in isolated rat Purkinje neurons independent of CB1 receptor activation. The IC
U2 - 10.1152/jn.01227.2005
DO - 10.1152/jn.01227.2005
M3 - Article
SN - 0022-3077
VL - 96
SP - 1267
EP - 1277
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
IS - 3
ER -
