Capillary electrophoresis for the analysis of small-molecule pharmaceuticals

Kevin D. Altria; Alex Marsh; Cari Sänger-van de Griend

doi:10.1002/elps.200600030

Capillary electrophoresis for the analysis of small-molecule pharmaceuticals

Kevin D. Altria^*, Alex Marsh, Cari Sänger-van de Griend

^*Corresponding author for this work

BioAnalytical Chemistry

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pK_a of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.

Original language	English
Pages (from-to)	2263-2282
Number of pages	20
Journal	Electrophoresis
Volume	27
Issue number	12
DOIs	https://doi.org/10.1002/elps.200600030
Publication status	Published - Jun 2006

Keywords

Capillary electrophoresis
Chiral separation
Log P determination
Pharmaceuticals
pK determination

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title = "Capillary electrophoresis for the analysis of small-molecule pharmaceuticals",

abstract = "This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pKa of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.",

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author = "Altria, {Kevin D.} and Alex Marsh and {S{\"a}nger-van de Griend}, Cari",

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AU - Marsh, Alex

AU - Sänger-van de Griend, Cari

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N2 - This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pKa of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.

AB - This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pKa of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.

KW - Capillary electrophoresis

KW - Chiral separation

KW - Log P determination

KW - Pharmaceuticals

KW - pK determination

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Capillary electrophoresis for the analysis of small-molecule pharmaceuticals

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Keywords

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