CARD15 gene mutations are not associated with ankylosing spondylitis.

M van der Paardt, J.B.A. Crusius, M.H. Koning, L.S. Murillo, RJ van de Stadt, B.A.C. Dijkmans, A.S. Pena, I.E. van der Horst - Bruinsma

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    An insertion mutation at nucleotide 3020 (3020insC) and a missense mutation G2722C in the CARD15 gene on chromosome 16p have been reported to be associated with Crohn's disease (CD). The protein encoded by the CARD15 gene is expressed in peripheral monocytes and regulates apoptosis and NF-κB activation, factors which play an important role in inflammation. Since CD and ankylosing spondylitis (AS) are interrelated disorders, we have investigated whether these mutations in the CARD 15 gene are also associated with AS. We studied 113 unrelated AS patients and 152 unrelated healthy controls. No significant differences were found between patients and controls in the prevalence of the insertion 3020insC mutation and the G2722C missense mutation, OR = 1.36, 95% CI: 0.27-6.84, P = 0.70 and OR = 0. 58; 95% CI: 0. 18-1.94; P = 0.38, respectively. We conclude that the insertion 3020insC mutation and the G2722C missense mutation in the CARD15 gene are not involved in the susceptibility to AS. © 2003 Nature Publishing Group All rights reserved.
    Original languageEnglish
    Pages (from-to)77-8
    JournalGenes and Immunity
    Volume4
    Issue number1
    Early online date1 Jan 2003
    DOIs
    Publication statusPublished - 2003

    Fingerprint

    Dive into the research topics of 'CARD15 gene mutations are not associated with ankylosing spondylitis.'. Together they form a unique fingerprint.

    Cite this