Cardiovascular risk factors in cognitively impaired nursing home patients: A relationship with pain?

W.P. Achterberg, E.J.A. Scherder, A.M. Pot, M.W. Ribbe

Research output: Contribution to JournalArticleAcademicpeer-review


Cardiovascular risk factors (CRF) such as hypertension and diabetes mellitus favour the development of both vascular dementia (VaD) and Alzheimer's disease (AD). The resulting deafferentation may increase the experience of pain in VaD and in AD. The goal of the present study was to examine the relationship between CRF and pain in a sample of 107 cognitively impaired nursing home patients who had also a chronic pain condition. The prevalence of pain in patients with hypertension or diabetes mellitus was higher (25/41 = 61% of them had pain) than those without diabetes or hypertension (of whom 24/66 = 36.4% had pain, p = 0.017). In a multivariate logistic regression model (adjusted for gender, age and depression) the presence of diabetes or hypertension was a risk indicator for pain: odds ratio: 3.48, p = 0.005, 95% CI: 1.45-8.38. This finding supports the hypothesis that as a result of CRF, disruptions of cortico-cortico and cortico-subcortical pathways occur, and consequently, enhances pain in this group of patients. © 2006 European Federation of Chapters of the International Association for the Study of Pain.
Original languageEnglish
Pages (from-to)707-710
Number of pages4
JournalEuropean Journal of Pain
Issue number6
Publication statusPublished - Aug 2007


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