Case Studies in Cellular Stress: Defining Adversity/Adaptation Tipping Points

Alistair Middleton, Sarah Cooper, Tom Cull, Richard Stark, Yeyejide Adeleye, Kim Boekelheide, Rebecca Clewell, Paul Jennings, Jiabin Guo, Chao Liu, Patrick McMullen, Shuangqing Peng, Imran Shah, Pam Spencer, Kas Subramanian, Russell S. Thomas, Bob van de Water, Carl Westmoreland, Andrew White, Qiang ZhangPaul L. Carmichael

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Abstract Between February 15 and 17, 2016, a workshop was held in London, hosted by Unilever's Safety and Environmental Assurance Centre, which sought to explore determinations of cellular stress as part of the data required for next-generation risk assessments, considering how to define tipping points between adverse and adaptive events in response to chemical agents. This event brought together a significant group of scientists and risk assessors, all of whom were involved in developing such safety assessments, to review the science. Over 3 days, the group reflected on their collective experience and sought to make some conclusions on ways forward to further develop this area; considering current thinking and vision for the use and acceptance of cellular stress pathways for safety assessment.
Original languageEnglish
Pages (from-to)199-210
Number of pages12
JournalApplied In Vitro Toxicology
Volume3
Issue number2
DOIs
Publication statusPublished - 7 Apr 2017

Bibliographical note

doi: 10.1089/aivt.2017.0003

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