Catalytic Asymmetric Synthesis of Diketopiperazines by Intramolecular Tsuji-Trost Allylation

Matteo Faltracco, Silvia Cotogno, Christophe M.L. Vande Velde, Eelco Ruijter

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

We report the intramolecular Tsuji-Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asymmetric construction of a broad range of these medicinally important heterocycles under mild conditions, in two steps from cheap, commercially available starting materials.

Original languageEnglish
Pages (from-to)12058-12070
Number of pages13
JournalThe Journal of organic chemistry
Volume84
Issue number18
Early online date26 Aug 2019
DOIs
Publication statusPublished - 20 Sep 2019

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