Catalytic C3 aza-alkylation of indoles

E. Bonandi, D. Perdicchia, E. Colombo, F. Foschi, P. Marzullo, D. Passarella

Research output: Contribution to JournalReview articleAcademicpeer-review


© 2020 The Royal Society of Chemistry.The aza-alkylation reaction at indole's C3 position allows the introduction of a differently substituted aminomethyl group, with the formation of a new stereogenic centre. The reaction involves essentially three different partners: an indole, aldehyde and amine. The formation of the reactive iminium species can be catalyzed by metals, Brønsted acids, Lewis acids or organocatalysts. The stereoselective reaction is feasible with satisfactory outcomes. This review summarizes the recent (2000-2019) meaningful papers in which the in-depth study and exploitation of this reactivity are reported.
Original languageEnglish
Pages (from-to)6211-6235
JournalOrganic and Biomolecular Chemistry
Issue number32
Publication statusPublished - 28 Aug 2020
Externally publishedYes


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