TY - JOUR
T1 - Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study
AU - Lin, B.
AU - Hottenga, J.J.
AU - Abdellaoui, A.
AU - Dolan, C.V.
AU - de Geus, E.J.C.
AU - Kluft, C.
AU - Boomsma, D.I.
AU - Willemsen, G.
PY - 2016
Y1 - 2016
N2 - Aim: Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are biomarkers for disease development, for whom little is known about causes of variation in the general population. Materials & methods: We estimated the heritability of PLR and NLR and examined their association with gender, demographic, lifestyle and environmental factors in a Dutch nonpatient twin family population (n = 8108). Results: Heritability was estimated at 64% for PLR and 36% for NLR. Men had on average higher NLR, but lower PLR levels than women. PLR and NLR increased significantly with age, decreased in colder months and showed small but significant sex- and age-specific associations with body composition and smoking. Conclusion: NLR and PLR levels are heritable and influenced by age, sex and environmental factors, such as seasonal conditions and lifestyle.
AB - Aim: Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are biomarkers for disease development, for whom little is known about causes of variation in the general population. Materials & methods: We estimated the heritability of PLR and NLR and examined their association with gender, demographic, lifestyle and environmental factors in a Dutch nonpatient twin family population (n = 8108). Results: Heritability was estimated at 64% for PLR and 36% for NLR. Men had on average higher NLR, but lower PLR levels than women. PLR and NLR increased significantly with age, decreased in colder months and showed small but significant sex- and age-specific associations with body composition and smoking. Conclusion: NLR and PLR levels are heritable and influenced by age, sex and environmental factors, such as seasonal conditions and lifestyle.
U2 - 10.2217/bmm-2016-0147
DO - 10.2217/bmm-2016-0147
M3 - Article
SN - 1752-0363
VL - 10
SP - 1061
EP - 1072
JO - Biomarkers in medicine
JF - Biomarkers in medicine
IS - 10
ER -
