CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival

Evelyna Derhovanessian, Sijia Chen, Andrea B Maier, Karin Hähnel, Anton J M de Craen, Helene Roelofs, Rudi Westendorp, Graham Pawelec

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

CD4(+) regulatory T cells (Tregs) are a distinct population of T cells involved in maintaining peripheral tolerance to self-antigens. Several studies have shown increased frequency and number of Tregs in the elderly. Whether such an increase has any clinical relevance has not been addressed. Here, we have analyzed circulating Tregs in 114 donors between the ages of 18 and 89 years and assessed their implications for survival of the very elderly. In line with previously published data, we observed higher proportions of Tregs in the elderly. Expression of chemokine receptor 4 (CCR4) by Tregs has been shown to characterize antigen-primed activated Tregs with immediate suppressive function. Thus we further analyzed Tregs expressing or lacking this chemokine receptor. There were more CCR4(+) and CCR4(-) Tregs in the elderly than the young. Finally, using a subset of 48 elderly donors participating in the Leiden 85-plus study we documented that people with greater median frequencies of CCR4(+) Tregs enjoyed a better 8-year survival rate than those with lower frequencies of these cells. Our data, demonstrating for the first time a positive correlation between increased frequency of Tregs and survival in the elderly, imply an increasing importance of controlling inappropriate immune responses and inflammation as we grew old.

Original languageEnglish
Pages (from-to)917-23
Number of pages7
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume70
Issue number8
DOIs
Publication statusPublished - Aug 2015

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Chemokine Receptors
Regulatory T-Lymphocytes
Tissue Donors
Peripheral Tolerance
Autoantigens
Inflammation
T-Lymphocytes
Antigens
Population

Bibliographical note

© The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/immunology
  • C-Reactive Protein/analysis
  • Cytomegalovirus Infections/immunology
  • Humans
  • Middle Aged
  • Receptors, CCR4/analysis
  • T-Lymphocytes, Regulatory/physiology

Cite this

Derhovanessian, Evelyna ; Chen, Sijia ; Maier, Andrea B ; Hähnel, Karin ; de Craen, Anton J M ; Roelofs, Helene ; Westendorp, Rudi ; Pawelec, Graham. / CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival. In: The journals of gerontology. Series A, Biological sciences and medical sciences. 2015 ; Vol. 70, No. 8. pp. 917-23.
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CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival. / Derhovanessian, Evelyna; Chen, Sijia; Maier, Andrea B; Hähnel, Karin; de Craen, Anton J M; Roelofs, Helene; Westendorp, Rudi; Pawelec, Graham.

In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 70, No. 8, 08.2015, p. 917-23.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival

AU - Derhovanessian, Evelyna

AU - Chen, Sijia

AU - Maier, Andrea B

AU - Hähnel, Karin

AU - de Craen, Anton J M

AU - Roelofs, Helene

AU - Westendorp, Rudi

AU - Pawelec, Graham

N1 - © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2015/8

Y1 - 2015/8

N2 - CD4(+) regulatory T cells (Tregs) are a distinct population of T cells involved in maintaining peripheral tolerance to self-antigens. Several studies have shown increased frequency and number of Tregs in the elderly. Whether such an increase has any clinical relevance has not been addressed. Here, we have analyzed circulating Tregs in 114 donors between the ages of 18 and 89 years and assessed their implications for survival of the very elderly. In line with previously published data, we observed higher proportions of Tregs in the elderly. Expression of chemokine receptor 4 (CCR4) by Tregs has been shown to characterize antigen-primed activated Tregs with immediate suppressive function. Thus we further analyzed Tregs expressing or lacking this chemokine receptor. There were more CCR4(+) and CCR4(-) Tregs in the elderly than the young. Finally, using a subset of 48 elderly donors participating in the Leiden 85-plus study we documented that people with greater median frequencies of CCR4(+) Tregs enjoyed a better 8-year survival rate than those with lower frequencies of these cells. Our data, demonstrating for the first time a positive correlation between increased frequency of Tregs and survival in the elderly, imply an increasing importance of controlling inappropriate immune responses and inflammation as we grew old.

AB - CD4(+) regulatory T cells (Tregs) are a distinct population of T cells involved in maintaining peripheral tolerance to self-antigens. Several studies have shown increased frequency and number of Tregs in the elderly. Whether such an increase has any clinical relevance has not been addressed. Here, we have analyzed circulating Tregs in 114 donors between the ages of 18 and 89 years and assessed their implications for survival of the very elderly. In line with previously published data, we observed higher proportions of Tregs in the elderly. Expression of chemokine receptor 4 (CCR4) by Tregs has been shown to characterize antigen-primed activated Tregs with immediate suppressive function. Thus we further analyzed Tregs expressing or lacking this chemokine receptor. There were more CCR4(+) and CCR4(-) Tregs in the elderly than the young. Finally, using a subset of 48 elderly donors participating in the Leiden 85-plus study we documented that people with greater median frequencies of CCR4(+) Tregs enjoyed a better 8-year survival rate than those with lower frequencies of these cells. Our data, demonstrating for the first time a positive correlation between increased frequency of Tregs and survival in the elderly, imply an increasing importance of controlling inappropriate immune responses and inflammation as we grew old.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging/immunology

KW - C-Reactive Protein/analysis

KW - Cytomegalovirus Infections/immunology

KW - Humans

KW - Middle Aged

KW - Receptors, CCR4/analysis

KW - T-Lymphocytes, Regulatory/physiology

U2 - 10.1093/gerona/glu128

DO - 10.1093/gerona/glu128

M3 - Article

VL - 70

SP - 917

EP - 923

JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

SN - 1079-5006

IS - 8

ER -