Cellular functions of the amyloid precursor protein from development to dementia

Rik van der Kant, Lawrence S B Goldstein

Research output: Contribution to JournalReview articleAcademicpeer-review


Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ fragments of APP are the major constituent of AD-associated amyloid plaques, and mutations or duplications of the gene coding for APP can cause familial AD. Here we review the roles of APP in neuronal development, signaling, intracellular transport, and other aspects of neuronal homeostasis. We suggest that APP acts as a signaling nexus that transduces information about a range of extracellular conditions, including neuronal damage, to induction of intracellular signaling events. Subtle disruptions of APP signaling functions may be major contributors to AD-causing neuronal dysfunction.

Original languageEnglish
Pages (from-to)502-15
Number of pages14
JournalDev Cell
Issue number4
Publication statusPublished - 23 Feb 2015
Externally publishedYes


  • Amyloid beta-Protein Precursor/genetics
  • Animals
  • Dementia/genetics
  • Humans
  • Mutation/genetics
  • Neurogenesis/genetics
  • Neurons/metabolism
  • Protein Processing, Post-Translational/genetics


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