Abstract
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 813-827 |
| Number of pages | 15 |
| Journal | Cell |
| Volume | 179 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 31 Oct 2019 |
Fingerprint
Bibliographical note
Copyright © 2019 Elsevier Inc. All rights reserved.Cite this
}
Cellular Senescence : Defining a Path Forward. / Gorgoulis, Vassilis; Adams, Peter D.; Alimonti, Andrea; Bennett, Dorothy C.; Bischof, Oliver; Bishop, Cleo; Campisi, Judith; Collado, Manuel; Evangelou, Konstantinos; Ferbeyre, Gerardo; Gil, Jesús; Hara, Eiji; Krizhanovsky, Valery; Jurk, Diana; Maier, Andrea B.; Narita, Masashi; Niedernhofer, Laura; Passos, João F.; Robbins, Paul D.; Schmitt, Clemens A.; Sedivy, John; Vougas, Konstantinos; von Zglinicki, Thomas; Zhou, Daohong; Serrano, Manuel; Demaria, Marco.
In: Cell, Vol. 179, No. 4, 31.10.2019, p. 813-827.Research output: Contribution to Journal › Review article › Academic › peer-review
TY - JOUR
T1 - Cellular Senescence
T2 - Defining a Path Forward
AU - Gorgoulis, Vassilis
AU - Adams, Peter D.
AU - Alimonti, Andrea
AU - Bennett, Dorothy C.
AU - Bischof, Oliver
AU - Bishop, Cleo
AU - Campisi, Judith
AU - Collado, Manuel
AU - Evangelou, Konstantinos
AU - Ferbeyre, Gerardo
AU - Gil, Jesús
AU - Hara, Eiji
AU - Krizhanovsky, Valery
AU - Jurk, Diana
AU - Maier, Andrea B.
AU - Narita, Masashi
AU - Niedernhofer, Laura
AU - Passos, João F.
AU - Robbins, Paul D.
AU - Schmitt, Clemens A.
AU - Sedivy, John
AU - Vougas, Konstantinos
AU - von Zglinicki, Thomas
AU - Zhou, Daohong
AU - Serrano, Manuel
AU - Demaria, Marco
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019/10/31
Y1 - 2019/10/31
N2 - Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
AB - Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
UR - http://www.scopus.com/inward/record.url?scp=85074054595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074054595&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2019.10.005
DO - 10.1016/j.cell.2019.10.005
M3 - Review article
VL - 179
SP - 813
EP - 827
JO - Cell
JF - Cell
SN - 0092-8674
IS - 4
ER -