Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis; Peter D. Adams; Andrea Alimonti; Dorothy C. Bennett; Oliver Bischof; Cleo Bishop; Judith Campisi; Manuel Collado; Konstantinos Evangelou; Gerardo Ferbeyre; Jesús Gil; Eiji Hara; Valery Krizhanovsky; Diana Jurk; Andrea B. Maier; Masashi Narita; Laura Niedernhofer; João F. Passos; Paul D. Robbins; Clemens A. Schmitt; John Sedivy; Konstantinos Vougas; Thomas von Zglinicki; Daohong Zhou; Manuel Serrano; Marco Demaria

doi:10.1016/j.cell.2019.10.005

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis^*, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. SchmittJohn Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria

^*Corresponding author for this work

Neuromechanics

Research output: Contribution to Journal › Review article › Academic › peer-review

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Abstract

Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

Original language	English
Pages (from-to)	813-827
Number of pages	15
Journal	Cell
Volume	179
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2019.10.005
Publication status	Published - 31 Oct 2019

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10.1016/j.cell.2019.10.005

Cellular Senescence_Defining a Path ForwardFinal published version, 1.06 MBLicence: Article 25fa Dutch Copyright Act

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Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., Gil, J., Hara, E., Krizhanovsky, V., Jurk, D., Maier, A. B., Narita, M., Niedernhofer, L., Passos, J. F., Robbins, P. D., ... Demaria, M. (2019). Cellular Senescence: Defining a Path Forward. Cell, 179(4), 813-827. https://doi.org/10.1016/j.cell.2019.10.005

Gorgoulis, Vassilis ; Adams, Peter D. ; Alimonti, Andrea ; Bennett, Dorothy C. ; Bischof, Oliver ; Bishop, Cleo ; Campisi, Judith ; Collado, Manuel ; Evangelou, Konstantinos ; Ferbeyre, Gerardo ; Gil, Jesús ; Hara, Eiji ; Krizhanovsky, Valery ; Jurk, Diana ; Maier, Andrea B. ; Narita, Masashi ; Niedernhofer, Laura ; Passos, João F. ; Robbins, Paul D. ; Schmitt, Clemens A. ; Sedivy, John ; Vougas, Konstantinos ; von Zglinicki, Thomas ; Zhou, Daohong ; Serrano, Manuel ; Demaria, Marco. / Cellular Senescence : Defining a Path Forward. In: Cell. 2019 ; Vol. 179, No. 4. pp. 813-827.

@article{715f0a09715141fc9abb04b03e534315,

title = "Cellular Senescence: Defining a Path Forward",

abstract = "Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.",

author = "Vassilis Gorgoulis and Adams, {Peter D.} and Andrea Alimonti and Bennett, {Dorothy C.} and Oliver Bischof and Cleo Bishop and Judith Campisi and Manuel Collado and Konstantinos Evangelou and Gerardo Ferbeyre and Jes{\'u}s Gil and Eiji Hara and Valery Krizhanovsky and Diana Jurk and Maier, {Andrea B.} and Masashi Narita and Laura Niedernhofer and Passos, {Jo{\~a}o F.} and Robbins, {Paul D.} and Schmitt, {Clemens A.} and John Sedivy and Konstantinos Vougas and {von Zglinicki}, Thomas and Daohong Zhou and Manuel Serrano and Marco Demaria",

year = "2019",

month = oct,

day = "31",

doi = "10.1016/j.cell.2019.10.005",

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Gorgoulis, V, Adams, PD, Alimonti, A, Bennett, DC, Bischof, O, Bishop, C, Campisi, J, Collado, M, Evangelou, K, Ferbeyre, G, Gil, J, Hara, E, Krizhanovsky, V, Jurk, D, Maier, AB, Narita, M, Niedernhofer, L, Passos, JF, Robbins, PD, Schmitt, CA, Sedivy, J, Vougas, K, von Zglinicki, T, Zhou, D, Serrano, M & Demaria, M 2019, 'Cellular Senescence: Defining a Path Forward', Cell, vol. 179, no. 4, pp. 813-827. https://doi.org/10.1016/j.cell.2019.10.005

Cellular Senescence : Defining a Path Forward. / Gorgoulis, Vassilis; Adams, Peter D.; Alimonti, Andrea; Bennett, Dorothy C.; Bischof, Oliver; Bishop, Cleo; Campisi, Judith; Collado, Manuel; Evangelou, Konstantinos; Ferbeyre, Gerardo; Gil, Jesús; Hara, Eiji; Krizhanovsky, Valery; Jurk, Diana; Maier, Andrea B.; Narita, Masashi; Niedernhofer, Laura; Passos, João F.; Robbins, Paul D.; Schmitt, Clemens A.; Sedivy, John; Vougas, Konstantinos; von Zglinicki, Thomas; Zhou, Daohong; Serrano, Manuel; Demaria, Marco.

In: Cell, Vol. 179, No. 4, 31.10.2019, p. 813-827.

Research output: Contribution to Journal › Review article › Academic › peer-review

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T1 - Cellular Senescence

T2 - Defining a Path Forward

AU - Gorgoulis, Vassilis

AU - Adams, Peter D.

AU - Alimonti, Andrea

AU - Bennett, Dorothy C.

AU - Bischof, Oliver

AU - Bishop, Cleo

AU - Campisi, Judith

AU - Collado, Manuel

AU - Evangelou, Konstantinos

AU - Ferbeyre, Gerardo

AU - Gil, Jesús

AU - Hara, Eiji

AU - Krizhanovsky, Valery

AU - Jurk, Diana

AU - Maier, Andrea B.

AU - Narita, Masashi

AU - Niedernhofer, Laura

AU - Passos, João F.

AU - Robbins, Paul D.

AU - Schmitt, Clemens A.

AU - Sedivy, John

AU - Vougas, Konstantinos

AU - von Zglinicki, Thomas

AU - Zhou, Daohong

AU - Serrano, Manuel

AU - Demaria, Marco

PY - 2019/10/31

Y1 - 2019/10/31

N2 - Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

AB - Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

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