Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, João F. Passos, Paul D. Robbins, Clemens A. Schmitt & 6 others John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

Original languageEnglish
Pages (from-to)813-827
Number of pages15
JournalCell
Volume179
Issue number4
DOIs
Publication statusPublished - 31 Oct 2019

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Cell Aging
Biomarkers
Genes
Aging of materials
Cells
Physiological Phenomena
Cultured Cells

Bibliographical note

Copyright © 2019 Elsevier Inc. All rights reserved.

Cite this

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., ... Demaria, M. (2019). Cellular Senescence: Defining a Path Forward. Cell, 179(4), 813-827. https://doi.org/10.1016/j.cell.2019.10.005, https://doi.org/10.1016/j.cell.2019.10.005
Gorgoulis, Vassilis ; Adams, Peter D. ; Alimonti, Andrea ; Bennett, Dorothy C. ; Bischof, Oliver ; Bishop, Cleo ; Campisi, Judith ; Collado, Manuel ; Evangelou, Konstantinos ; Ferbeyre, Gerardo ; Gil, Jesús ; Hara, Eiji ; Krizhanovsky, Valery ; Jurk, Diana ; Maier, Andrea B. ; Narita, Masashi ; Niedernhofer, Laura ; Passos, João F. ; Robbins, Paul D. ; Schmitt, Clemens A. ; Sedivy, John ; Vougas, Konstantinos ; von Zglinicki, Thomas ; Zhou, Daohong ; Serrano, Manuel ; Demaria, Marco. / Cellular Senescence : Defining a Path Forward. In: Cell. 2019 ; Vol. 179, No. 4. pp. 813-827.
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title = "Cellular Senescence: Defining a Path Forward",
abstract = "Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.",
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Gorgoulis, V, Adams, PD, Alimonti, A, Bennett, DC, Bischof, O, Bishop, C, Campisi, J, Collado, M, Evangelou, K, Ferbeyre, G, Gil, J, Hara, E, Krizhanovsky, V, Jurk, D, Maier, AB, Narita, M, Niedernhofer, L, Passos, JF, Robbins, PD, Schmitt, CA, Sedivy, J, Vougas, K, von Zglinicki, T, Zhou, D, Serrano, M & Demaria, M 2019, 'Cellular Senescence: Defining a Path Forward' Cell, vol. 179, no. 4, pp. 813-827. https://doi.org/10.1016/j.cell.2019.10.005, https://doi.org/10.1016/j.cell.2019.10.005

Cellular Senescence : Defining a Path Forward. / Gorgoulis, Vassilis; Adams, Peter D.; Alimonti, Andrea; Bennett, Dorothy C.; Bischof, Oliver; Bishop, Cleo; Campisi, Judith; Collado, Manuel; Evangelou, Konstantinos; Ferbeyre, Gerardo; Gil, Jesús; Hara, Eiji; Krizhanovsky, Valery; Jurk, Diana; Maier, Andrea B.; Narita, Masashi; Niedernhofer, Laura; Passos, João F.; Robbins, Paul D.; Schmitt, Clemens A.; Sedivy, John; Vougas, Konstantinos; von Zglinicki, Thomas; Zhou, Daohong; Serrano, Manuel; Demaria, Marco.

In: Cell, Vol. 179, No. 4, 31.10.2019, p. 813-827.

Research output: Contribution to JournalReview articleAcademicpeer-review

TY - JOUR

T1 - Cellular Senescence

T2 - Defining a Path Forward

AU - Gorgoulis, Vassilis

AU - Adams, Peter D.

AU - Alimonti, Andrea

AU - Bennett, Dorothy C.

AU - Bischof, Oliver

AU - Bishop, Cleo

AU - Campisi, Judith

AU - Collado, Manuel

AU - Evangelou, Konstantinos

AU - Ferbeyre, Gerardo

AU - Gil, Jesús

AU - Hara, Eiji

AU - Krizhanovsky, Valery

AU - Jurk, Diana

AU - Maier, Andrea B.

AU - Narita, Masashi

AU - Niedernhofer, Laura

AU - Passos, João F.

AU - Robbins, Paul D.

AU - Schmitt, Clemens A.

AU - Sedivy, John

AU - Vougas, Konstantinos

AU - von Zglinicki, Thomas

AU - Zhou, Daohong

AU - Serrano, Manuel

AU - Demaria, Marco

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/10/31

Y1 - 2019/10/31

N2 - Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

AB - Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

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U2 - 10.1016/j.cell.2019.10.005

DO - 10.1016/j.cell.2019.10.005

M3 - Review article

VL - 179

SP - 813

EP - 827

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -

Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C et al. Cellular Senescence: Defining a Path Forward. Cell. 2019 Oct 31;179(4):813-827. https://doi.org/10.1016/j.cell.2019.10.005, https://doi.org/10.1016/j.cell.2019.10.005