Cerebral white matter in early puberty is associated with luteinizing hormone concentrations.

J.S. Peper, R.M. Brouwer, H.G. Schnack, G.C.M. van Baal, M. van Leeuwen, S.M. van den Berg, H.A. Delemarre-van de Waal, A.L. Janke, D.L. Collins, A.C. Evans, D.I. Boomsma, R.S. Kahn, H.E. Hulshoff Pol

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)909-915
JournalPsychoneuroendocrinology
Volume33
Issue number7
DOIs
Publication statusPublished - 2008

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Puberty
Luteinizing Hormone
White Matter
Dizygotic Twins
Monozygotic Twins
Corpus Callosum
Temporal Lobe
Genes
Gray Matter
Growth

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Peper, J. S., Brouwer, R. M., Schnack, H. G., van Baal, G. C. M., van Leeuwen, M., van den Berg, S. M., ... Hulshoff Pol, H. E. (2008). Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. Psychoneuroendocrinology, 33(7), 909-915. https://doi.org/10.1016/j.psyneuen.2008.03.017
Peper, J.S. ; Brouwer, R.M. ; Schnack, H.G. ; van Baal, G.C.M. ; van Leeuwen, M. ; van den Berg, S.M. ; Delemarre-van de Waal, H.A. ; Janke, A.L. ; Collins, D.L. ; Evans, A.C. ; Boomsma, D.I. ; Kahn, R.S. ; Hulshoff Pol, H.E. / Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. In: Psychoneuroendocrinology. 2008 ; Vol. 33, No. 7. pp. 909-915.
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title = "Cerebral white matter in early puberty is associated with luteinizing hormone concentrations.",
abstract = "Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence. {\circledC} 2008 Elsevier Ltd. All rights reserved.",
author = "J.S. Peper and R.M. Brouwer and H.G. Schnack and {van Baal}, G.C.M. and {van Leeuwen}, M. and {van den Berg}, S.M. and {Delemarre-van de Waal}, H.A. and A.L. Janke and D.L. Collins and A.C. Evans and D.I. Boomsma and R.S. Kahn and {Hulshoff Pol}, H.E.",
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Peper, JS, Brouwer, RM, Schnack, HG, van Baal, GCM, van Leeuwen, M, van den Berg, SM, Delemarre-van de Waal, HA, Janke, AL, Collins, DL, Evans, AC, Boomsma, DI, Kahn, RS & Hulshoff Pol, HE 2008, 'Cerebral white matter in early puberty is associated with luteinizing hormone concentrations.' Psychoneuroendocrinology, vol. 33, no. 7, pp. 909-915. https://doi.org/10.1016/j.psyneuen.2008.03.017

Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. / Peper, J.S.; Brouwer, R.M.; Schnack, H.G.; van Baal, G.C.M.; van Leeuwen, M.; van den Berg, S.M.; Delemarre-van de Waal, H.A.; Janke, A.L.; Collins, D.L.; Evans, A.C.; Boomsma, D.I.; Kahn, R.S.; Hulshoff Pol, H.E.

In: Psychoneuroendocrinology, Vol. 33, No. 7, 2008, p. 909-915.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Cerebral white matter in early puberty is associated with luteinizing hormone concentrations.

AU - Peper, J.S.

AU - Brouwer, R.M.

AU - Schnack, H.G.

AU - van Baal, G.C.M.

AU - van Leeuwen, M.

AU - van den Berg, S.M.

AU - Delemarre-van de Waal, H.A.

AU - Janke, A.L.

AU - Collins, D.L.

AU - Evans, A.C.

AU - Boomsma, D.I.

AU - Kahn, R.S.

AU - Hulshoff Pol, H.E.

PY - 2008

Y1 - 2008

N2 - Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence. © 2008 Elsevier Ltd. All rights reserved.

AB - Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence. © 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.psyneuen.2008.03.017

DO - 10.1016/j.psyneuen.2008.03.017

M3 - Article

VL - 33

SP - 909

EP - 915

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

IS - 7

ER -

Peper JS, Brouwer RM, Schnack HG, van Baal GCM, van Leeuwen M, van den Berg SM et al. Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. Psychoneuroendocrinology. 2008;33(7):909-915. https://doi.org/10.1016/j.psyneuen.2008.03.017