Challenges in identifying antibiotic resistance targets for point-of-care diagnostics in general practice

Konstantinos Mitsakakis, Wendy E Kaman, Gijs Elshout, Mara Specht, John P Hays

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

General practitioners stand at the front line of healthcare provision and have a pivotal role in the fight against increasing antibiotic resistance. In this respect, targeted antibiotic prescribing by general practitioners would help reduce the unnecessary use of antibiotics, leading to reduced treatment failures, fewer side-effects for patients and a reduction in the (global) spread of antibiotic resistances. Current 'gold standard' antibiotic resistance detection strategies tend to be slow, taking up to 48 h to obtain a result, although the implementation of point-of-care testing by general practitioners could help achieve the goal of targeted antibiotic prescribing practices. However, deciding on which antibiotic resistances to include in a point-of-care diagnostic is not a trivial task, as outlined in this publication.

Original languageEnglish
Pages (from-to)1157-1164
Number of pages8
JournalFuture Microbiology
Volume13
Issue number10
DOIs
Publication statusPublished - Aug 2018

Funding

This publication was supported by a Horizon2020 EU grant under grant agreement GA-633780 (‘DIAGORAS’ – www.diagoras.eu). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

FundersFunder number
Horizon2020 EUGA-633780
Horizon 2020 Framework Programme633780

    Keywords

    • Anti-Bacterial Agents/therapeutic use
    • Diagnostic Tests, Routine/standards
    • Drug Resistance, Microbial/genetics
    • General Practice/standards
    • Humans
    • Inappropriate Prescribing/prevention & control
    • Microbiota/genetics
    • Physician-Patient Relations
    • Point-of-Care Systems/standards
    • Point-of-Care Testing/standards

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