Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults

Liset E.M. Elstgeest, Elisa J. De Koning, Ingeborg A. Brouwer, Natasja M. Van Schoor, Brenda W.J.H. Penninx, Marjolein Visser

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective: Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. Design: A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. Methods: Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65-88y, n = 173) and in 2002/2003 and 6 years later in the younger cohort (55-65 years, n = 450). At these time points, depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Associations were tested by multiple linear regression analyses. Results: During follow-up, serum 25(OH)D concentrations increased in 32.4% of the older cohort and in 69.8% of the younger cohort. In the older cohort, change in 25(OH)D was not associated with change in CES-D score. In the younger cohort, no associations were observed in participants with higher baseline 25(OH)D concentrations (>58.6 nmol/L), but in those with lower baseline 25(OH)D concentrations, an increase in 25(OH)D was associated with a decrease in CES-D score (adjusted B per 10 nmol/L 25(OH)D increase: -0.62 (95% CI: -1.17, -0.07)). Conclusions: Our study suggests that over 6 years, an increase in serum 25(OH)D is associated with a small decrease in depressive symptoms in young older adults with lower baseline 25(OH)D. Well-designed intervention trials are required to determine causality.

Original languageEnglish
Pages (from-to)239-249
Number of pages11
JournalEuropean Journal of Endocrinology
Volume179
Issue number4
DOIs
Publication statusPublished - Oct 2018

Fingerprint

Depression
Serum
Epidemiologic Studies
Prospective Studies
25-hydroxyvitamin D
Vitamin D
Causality
Longitudinal Studies
Young Adult
Linear Models
Regression Analysis
Population

Cite this

@article{2a7ddd361e724481aa40db20cdba19aa,
title = "Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults",
abstract = "Objective: Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. Design: A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. Methods: Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65-88y, n = 173) and in 2002/2003 and 6 years later in the younger cohort (55-65 years, n = 450). At these time points, depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Associations were tested by multiple linear regression analyses. Results: During follow-up, serum 25(OH)D concentrations increased in 32.4{\%} of the older cohort and in 69.8{\%} of the younger cohort. In the older cohort, change in 25(OH)D was not associated with change in CES-D score. In the younger cohort, no associations were observed in participants with higher baseline 25(OH)D concentrations (>58.6 nmol/L), but in those with lower baseline 25(OH)D concentrations, an increase in 25(OH)D was associated with a decrease in CES-D score (adjusted B per 10 nmol/L 25(OH)D increase: -0.62 (95{\%} CI: -1.17, -0.07)). Conclusions: Our study suggests that over 6 years, an increase in serum 25(OH)D is associated with a small decrease in depressive symptoms in young older adults with lower baseline 25(OH)D. Well-designed intervention trials are required to determine causality.",
author = "Elstgeest, {Liset E.M.} and {De Koning}, {Elisa J.} and Brouwer, {Ingeborg A.} and {Van Schoor}, {Natasja M.} and Penninx, {Brenda W.J.H.} and Marjolein Visser",
year = "2018",
month = "10",
doi = "10.1530/EJE-18-0187",
language = "English",
volume = "179",
pages = "239--249",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "4",

}

Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults. / Elstgeest, Liset E.M.; De Koning, Elisa J.; Brouwer, Ingeborg A.; Van Schoor, Natasja M.; Penninx, Brenda W.J.H.; Visser, Marjolein.

In: European Journal of Endocrinology, Vol. 179, No. 4, 10.2018, p. 239-249.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults

AU - Elstgeest, Liset E.M.

AU - De Koning, Elisa J.

AU - Brouwer, Ingeborg A.

AU - Van Schoor, Natasja M.

AU - Penninx, Brenda W.J.H.

AU - Visser, Marjolein

PY - 2018/10

Y1 - 2018/10

N2 - Objective: Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. Design: A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. Methods: Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65-88y, n = 173) and in 2002/2003 and 6 years later in the younger cohort (55-65 years, n = 450). At these time points, depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Associations were tested by multiple linear regression analyses. Results: During follow-up, serum 25(OH)D concentrations increased in 32.4% of the older cohort and in 69.8% of the younger cohort. In the older cohort, change in 25(OH)D was not associated with change in CES-D score. In the younger cohort, no associations were observed in participants with higher baseline 25(OH)D concentrations (>58.6 nmol/L), but in those with lower baseline 25(OH)D concentrations, an increase in 25(OH)D was associated with a decrease in CES-D score (adjusted B per 10 nmol/L 25(OH)D increase: -0.62 (95% CI: -1.17, -0.07)). Conclusions: Our study suggests that over 6 years, an increase in serum 25(OH)D is associated with a small decrease in depressive symptoms in young older adults with lower baseline 25(OH)D. Well-designed intervention trials are required to determine causality.

AB - Objective: Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. Design: A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. Methods: Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65-88y, n = 173) and in 2002/2003 and 6 years later in the younger cohort (55-65 years, n = 450). At these time points, depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Associations were tested by multiple linear regression analyses. Results: During follow-up, serum 25(OH)D concentrations increased in 32.4% of the older cohort and in 69.8% of the younger cohort. In the older cohort, change in 25(OH)D was not associated with change in CES-D score. In the younger cohort, no associations were observed in participants with higher baseline 25(OH)D concentrations (>58.6 nmol/L), but in those with lower baseline 25(OH)D concentrations, an increase in 25(OH)D was associated with a decrease in CES-D score (adjusted B per 10 nmol/L 25(OH)D increase: -0.62 (95% CI: -1.17, -0.07)). Conclusions: Our study suggests that over 6 years, an increase in serum 25(OH)D is associated with a small decrease in depressive symptoms in young older adults with lower baseline 25(OH)D. Well-designed intervention trials are required to determine causality.

UR - http://www.scopus.com/inward/record.url?scp=85054386087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054386087&partnerID=8YFLogxK

U2 - 10.1530/EJE-18-0187

DO - 10.1530/EJE-18-0187

M3 - Article

VL - 179

SP - 239

EP - 249

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 4

ER -