Changes in fat-free mass in obese subjects after weight loss: a comparison of body composition measures

K van der Kooy, R Leenen, P. Deurenberg, J C Seidell, K R Westerterp, J.G.A.J. Hautvast

Research output: Contribution to JournalArticleAcademicpeer-review


Estimates of body composition by densitometry were made in 84 apparently healthy subjects (42 men, 42 women) with a mean age of 40 +/- 6 years (mean +/- s.d.), before and after weight loss. The initial body mass index (BMI) was 30.7 +/- 2.3 kg/m2 and the achieved weight loss on a 4.2 MJ/day energy deficit diet for 13 weeks was 12.2 +/- 3.7 kg. The results by densitometry were compared with estimates obtained by four other techniques: deuterium oxide dilution, skinfold thickness, bioelectrical impedance (three equations) and BMI (two equations). The fat-free mass (FFM) loss estimated by densitometry in men and women was 2.8 +/- 1.8 kg and 1.3 +/- 1.3 kg respectively. The dilution technique gave comparable results with densitometry. The losses of FFM assessed by skinfold thicknesses, BMI and impedance equations were almost similar, but significantly larger than the reduction in FFM measured by densitometry. These deviations were mainly the result of significantly larger differences from densitometry before compared to after weight loss. No correlation was found between change in FFM by densitometry and change in resistance measured by the bioelectrical impedance method in both sexes. It is concluded that application of published prediction formulae in weight loss studies are less appropriate and will lead to changes in FFM that are significantly different from the changes estimated by densitometry or deuterium oxide dilution.

Original languageEnglish
Pages (from-to)675-83
Number of pages9
JournalInternational journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
Issue number9
Publication statusPublished - Sept 1992


  • Adult
  • Body Composition
  • Body Mass Index
  • Body Water
  • Densitometry
  • Electric Impedance
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obesity
  • Skinfold Thickness
  • Weight Loss
  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't


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