Changes in neuroreceptor funtion of tracheal smooth muscle following acute ozone exposure of guinea pigs.

H.J.M. van Hoof; H.P. Voss; K. Kramer; A.J.F. Boere; J.A.M.A. Dormans; L. van Bree; A. Bast

doi:10.1016/S0300-483X(96)03603-7

Changes in neuroreceptor funtion of tracheal smooth muscle following acute ozone exposure of guinea pigs.

H.J.M. van Hoof, H.P. Voss, K. Kramer, A.J.F. Boere, J.A.M.A. Dormans, L. van Bree, A. Bast

Medicinal chemistry

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Abstract

We studied the effect of in vivo ozone inhalation (3 ppm, 2 h) on neuroreceptor function in guinea pig tracheal smooth muscle in vitro and the role of the epithelial layer in this process. Changes in smooth muscle tension after stimulation of the muscarinic- and β-adrenergic receptor were recorded isometrically and stained tracheal tissue sections were histologically evaluated for changes in the epithelial and smooth muscle layer. Ozone exposure resulted in an increase in maximal contraction following stimulation of the muscarinic receptor, whereas pD

Original language	English
Pages (from-to)	159-169
Journal	Toxicology
Volume	120
DOIs	https://doi.org/10.1016/S0300-483X(96)03603-7
Publication status	Published - 1997

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10.1016/S0300-483X(96)03603-7

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title = "Changes in neuroreceptor funtion of tracheal smooth muscle following acute ozone exposure of guinea pigs.",

abstract = "We studied the effect of in vivo ozone inhalation (3 ppm, 2 h) on neuroreceptor function in guinea pig tracheal smooth muscle in vitro and the role of the epithelial layer in this process. Changes in smooth muscle tension after stimulation of the muscarinic- and β-adrenergic receptor were recorded isometrically and stained tracheal tissue sections were histologically evaluated for changes in the epithelial and smooth muscle layer. Ozone exposure resulted in an increase in maximal contraction following stimulation of the muscarinic receptor, whereas pD",

author = "{van Hoof}, H.J.M. and H.P. Voss and K. Kramer and A.J.F. Boere and J.A.M.A. Dormans and {van Bree}, L. and A. Bast",

year = "1997",

doi = "10.1016/S0300-483X(96)03603-7",

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AU - van Hoof, H.J.M.

AU - Voss, H.P.

AU - Kramer, K.

AU - Boere, A.J.F.

AU - Dormans, J.A.M.A.

AU - van Bree, L.

AU - Bast, A.

PY - 1997

Y1 - 1997

N2 - We studied the effect of in vivo ozone inhalation (3 ppm, 2 h) on neuroreceptor function in guinea pig tracheal smooth muscle in vitro and the role of the epithelial layer in this process. Changes in smooth muscle tension after stimulation of the muscarinic- and β-adrenergic receptor were recorded isometrically and stained tracheal tissue sections were histologically evaluated for changes in the epithelial and smooth muscle layer. Ozone exposure resulted in an increase in maximal contraction following stimulation of the muscarinic receptor, whereas pD

AB - We studied the effect of in vivo ozone inhalation (3 ppm, 2 h) on neuroreceptor function in guinea pig tracheal smooth muscle in vitro and the role of the epithelial layer in this process. Changes in smooth muscle tension after stimulation of the muscarinic- and β-adrenergic receptor were recorded isometrically and stained tracheal tissue sections were histologically evaluated for changes in the epithelial and smooth muscle layer. Ozone exposure resulted in an increase in maximal contraction following stimulation of the muscarinic receptor, whereas pD

U2 - 10.1016/S0300-483X(96)03603-7

DO - 10.1016/S0300-483X(96)03603-7

M3 - Article

SN - 0300-483X

VL - 120

SP - 159

EP - 169

JO - Toxicology

JF - Toxicology

ER -

Changes in neuroreceptor funtion of tracheal smooth muscle following acute ozone exposure of guinea pigs.

Abstract

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