Changes in Sexuality and Sexual Dysfunction over Time in the First Two Years after Treatment of Head and Neck Cancer

Margot A. Stone; Birgit I. Lissenberg-Witte; Remco de Bree; Jose A. Hardillo; Femke Lamers; Johannes A. Langendijk; C. René Leemans; Robert P. Takes; Femke Jansen; Irma M. Verdonck-de Leeuw

doi:10.3390/cancers15194755

Changes in Sexuality and Sexual Dysfunction over Time in the First Two Years after Treatment of Head and Neck Cancer

Margot A. Stone, Birgit I. Lissenberg-Witte, Remco de Bree, Jose A. Hardillo, Femke Lamers, Johannes A. Langendijk, C. René Leemans, Robert P. Takes, Femke Jansen, Irma M. Verdonck-de Leeuw

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The aim of this study was to investigate changes in sexuality and sexual dysfunction in head and neck cancer (HNC) patients in the first two years after treatment, in relation to the type of treatment. Data were used of 588 HNC patients participating in the prospective NETherlands Quality of life and Biomedical Cohort Study (NET-QUBIC) from diagnosis to 3, 6, 12 and 24 months after treatment. Primary outcome measures were the International Index of Erectile Function (IIEF) and the Female Sexual Function Index (FSFI). The total scores of the IIEF and FSFI were dichotomized into sexual (dys)function. In men, type of treatment was significantly associated with change in erectile function, orgasm, satisfaction with intercourse, and overall satisfaction. In women, type of treatment was significantly associated with change in desire, arousal, and orgasm. There were significant differences between treatment groups in change in dysfunctional sexuality. A deterioration in sexuality and sexual dysfunction from baseline to 3 months after treatment was observed especially in patients treated with chemoradiation. Changes in sexuality and sexual dysfunction in HNC patients were related to treatment, with an acute negative effect of chemoradiation. This effect on the various domains of sexuality seems to differ between men and women.

Original language	English
Article number	4755
Journal	Cancers
Volume	15
Issue number	19
DOIs	https://doi.org/10.3390/cancers15194755
Publication status	Published - 1 Oct 2023

Funding

This study was carried out using the research infrastructure within the NETherlands QUality of life and BIomedical Cohort study in head and neck cancer (NET-QUBIC) project funded by the Dutch Cancer Society (grant number VU 2013-5930). The funding body had no role in the study design, the data collection, analysis, and interpretation, nor the manuscript preparation.

Funders	Funder number
KWF Kankerbestrijding	VU 2013-5930

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title = "Changes in Sexuality and Sexual Dysfunction over Time in the First Two Years after Treatment of Head and Neck Cancer",

abstract = "The aim of this study was to investigate changes in sexuality and sexual dysfunction in head and neck cancer (HNC) patients in the first two years after treatment, in relation to the type of treatment. Data were used of 588 HNC patients participating in the prospective NETherlands Quality of life and Biomedical Cohort Study (NET-QUBIC) from diagnosis to 3, 6, 12 and 24 months after treatment. Primary outcome measures were the International Index of Erectile Function (IIEF) and the Female Sexual Function Index (FSFI). The total scores of the IIEF and FSFI were dichotomized into sexual (dys)function. In men, type of treatment was significantly associated with change in erectile function, orgasm, satisfaction with intercourse, and overall satisfaction. In women, type of treatment was significantly associated with change in desire, arousal, and orgasm. There were significant differences between treatment groups in change in dysfunctional sexuality. A deterioration in sexuality and sexual dysfunction from baseline to 3 months after treatment was observed especially in patients treated with chemoradiation. Changes in sexuality and sexual dysfunction in HNC patients were related to treatment, with an acute negative effect of chemoradiation. This effect on the various domains of sexuality seems to differ between men and women.",

author = "Stone, {Margot A.} and Lissenberg-Witte, {Birgit I.} and {de Bree}, Remco and Hardillo, {Jose A.} and Femke Lamers and Langendijk, {Johannes A.} and Leemans, {C. Ren{\'e}} and Takes, {Robert P.} and Femke Jansen and {Verdonck-de Leeuw}, {Irma M.}",

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AU - Stone, Margot A.

AU - Lissenberg-Witte, Birgit I.

AU - de Bree, Remco

AU - Hardillo, Jose A.

AU - Lamers, Femke

AU - Langendijk, Johannes A.

AU - Leemans, C. René

AU - Takes, Robert P.

AU - Jansen, Femke

AU - Verdonck-de Leeuw, Irma M.

PY - 2023/10/1

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Changes in Sexuality and Sexual Dysfunction over Time in the First Two Years after Treatment of Head and Neck Cancer

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