Childhood maltreatment modifies the relationship of depression with hippocampal volume

L. Gerritsen, L. van Velzen, L. Schmaal, Y. van der Graaf, N. van der Wee, M.J. van Tol, B.W.J.H. Penninx, M. Geerlings

    Research output: Contribution to JournalArticleAcademicpeer-review


    Childhood maltreatment (CM) may modify the relationship between major depressive disorder (MDD) and hippocampal volume reduction. To disentangle the impact of MDD and CM on hippocampal volume we investigated the association between MDD and hippocampal volume in persons with and without a history of CM in two independent cohorts. Method. We used data of 262 participants from the Netherlands Study of Depression and Anxiety (NESDA) (mean age 37 years, 32% male) and 636 participants from the SMART-Medea study (mean age 61 years, 81% male). In both studies a 12-month diagnosis of MDD and CM were assessed using a diagnostic interview. Hippocampal volume was measured in NESDA using FreeSurfer software on 3-T magnetic resonance (MR) images and in SMART it was manually outlined on 1.5-T MR images. With analysis of covariance adjusted for intracranial volume, age, gender and lifestyle factors we estimated the effects of MDD and CM on hippocampal volume. Results. In both cohorts CM was not significantly associated with hippocampal volume. After pooling the data MDD was associated with smaller hippocampal volume (B =-138.90 mm
    Original languageEnglish
    Pages (from-to)3517-3526
    JournalPsychological Medicine
    Issue number16
    Publication statusPublished - 2015


    Dive into the research topics of 'Childhood maltreatment modifies the relationship of depression with hippocampal volume'. Together they form a unique fingerprint.

    Cite this