Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime

N. Nikolic; D. Veselinovic; J. Vucina; H. Lingeman; K. Karljikovic-Rajic

doi:10.1016/S0731-7085(03)00230-9

Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime

N. Nikolic
, D. Veselinovic
, J. Vucina
, H. Lingeman
, K. Karljikovic-Rajic

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)

Original language	English
Pages (from-to)	1159-66
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/S0731-7085(03)00230-9
Publication status	Published - 2003

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10.1016/S0731-7085(03)00230-9

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abstract = "The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)",

author = "N. Nikolic and D. Veselinovic and J. Vucina and H. Lingeman and K. Karljikovic-Rajic",

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AU - Nikolic, N.

AU - Veselinovic, D.

AU - Vucina, J.

AU - Lingeman, H.

AU - Karljikovic-Rajic, K.

PY - 2003

Y1 - 2003

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AB - The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)

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UR - https://www.scopus.com/pages/publications/0043205804#tab=citedBy

U2 - 10.1016/S0731-7085(03)00230-9

DO - 10.1016/S0731-7085(03)00230-9

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JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

IS - 6

ER -

Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime

Abstract

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