Chromatin accessibility during human first-trimester neurodevelopment

Camiel C. A. Mannens, Lijuan Hu, Peter Lönnerberg, Marijn Schipper, Caleb C. Reagor, Xiaofei Li, Xiaoling He, Roger A. Barker, Erik Sundström, Danielle Posthuma, Sten Linnarsson

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The style of overriding plate deformation at subduction zones varies from backarc spreading and basin formation, as found in the Scotia Sea, to shortening and cordilleran orogeny, as observed in the Andes. Why this difference exists and why overriding plate extension occurs more frequently than shortening remains unexplained. In this contribution, various conceptual mechanisms of overriding plate deformation are reviewed and assessed. Time-evolving numerical models of buoyancy-driven subduction in three-dimensional space are presented to investigate the influence of subduction zone size and time on the style and rate of overriding plate deformation, and, more generally, on the geometry, kinematics and dynamics of subduction. The models demonstrate how time (temporal evolution, and its related parameter subduction depth) and subduction zone size (width, trench-parallel extent) control deformation style. Cordilleran orogeny occurs only for wide, mature subduction zones during subduction into the lower mantle, while narrow and intermediate-width subduction zones, and wide but young subduction zones, are characterized by overriding plate extension, even during lower mantle slab penetration for narrow and intermediate-width subduction zones and for subduction zone edges of wide subduction zones during early stage lower mantle penetration. This difference in deformation style is explained by the fact that subduction zone size, time and slab depth also control subduction kinematics, slab geometries, slab sinking directions, and mantle flow patterns. Narrow slabs, intermediate slabs, slab edges and short wide slabs generally have an important, slab-pull-driven, backward (oceanward) sinking component resulting in trench retreat and slab rollback, inducing strong local return flow patterns in the upper mantle close to the slab (toroidal for the narrow slabs, intermediate-width slabs and slab edges). The combination of strong local return flow near the slab and slab-pull-driven trench retreat induces deviatoric tension in the overriding plate through trenchward-increasing basal drag and subduction interface deviatoric tension, causing extension. In contrast, a wide slab, in particular that of an old subduction zone, generally sinks forward and subduction occurs mostly through trenchward subducting plate motion, inducing a strong whole-mantle asymmetric poloidal flow cell. The combination of strong poloidal flow-induced basal tractions at the base of the overriding plate that decrease trenchward and subduction interface deviatoric compression due to trenchward overriding plate motion and a relatively immobile subduction hinge induces deviatoric compression in the overriding plate, causing shortening, which is most pronounced in the centre of the wide subduction zone. Comparison between a global review of active subduction zones and the numerical modelling results shows consistent positive correlations for subducting plate velocity and negative correlations for trench velocity, overriding plate deformation rate and slab dip as a function of subduction zone size. Ultimately, the geodynamic models and subduction zone review provide a new explanation for the diversity of overriding plate deformation as exemplified by two endmembers, the small Scotia subduction zone (with backarc spreading) and large South American subduction zone (with shortening), for the non-uniform spatial and temporal occurrence of different deformation styles, and for the more frequent occurrence of active overriding plate extension compared to active overriding plate shortening on Earth.
Original languageEnglish
Pages (from-to)179-186
Number of pages24
JournalNature
Volume647
Issue number8088
Early online date1 May 2024
DOIs
Publication statusPublished - 6 Nov 2025

Funding

We thank the women who have decided to donate to science, making this study possible; the Developmental Tissue Bank (Department of Neurobiology, Care Sciences and Society, Karolinska Institutet) core facility, the Human Developmental Biology Resource (UK) and Cambridge University for providing prenatal tissue samples; Y.\u2009E.\u2009Li and B.\u2009Ren for hosting the online dataset; J.\u2009B.\u2009Munting for providing supplementary code used while training the CNN; E.\u2009Vinsland for assistance collecting samples; I.\u2009Kapustova for providing illustrations; and all members of the Linnarsson laboratory and M.\u2009Bartosovic, M.\u2009Kabbe and J.\u2009Hjerling-Leffler for discussions. This research was supported by the National Institute for Health and Care Research Cambridge Biomedical Research Centre (BRC-1215-20014). The views expressed are those of the authors and not necessarily those of the National Institute for Health and Care Research or the Department of Health and Social Care. This work is financed by the following grants: an Erling-Persson Foundation Human Developmental Cell Atlas grant (S.L.), Knut and Alice Wallenberg Foundation grants 2015.0041, 2018.0172 and 2018.0220 (S.L.), Swedish Foundation for Strategic Research SB16-0065 (S.L.) and EU Horizon2020 BRAINTIME project 874606 (S.L.). We also acknowledge support from the National Genomics Infrastructure in Stockholm financed by the Science for Life Laboratory, the Knut and Alice Wallenberg Foundation and the Swedish Research Council. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any author accepted manuscript version arising from this submission.

FundersFunder number
EU Horizon2020
Erling-Persson Foundation Human Developmental Cell Atlas
Science for Life Laboratory
Vetenskapsrådet
Horizon 2020 Framework Programme874606
NIHR Cambridge Biomedical Research CentreBRC-1215-20014
Stiftelsen för Strategisk ForskningSB16-0065
Knut och Alice Wallenbergs Stiftelse2018.0172, 2018.0220, 2015.0041

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