Chromosome 9: linkage for borderline personality disorder features.

M.A. Distel, J.J. Hottenga, T.J. Trull, D.I. Boomsma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective A large-scale twin study implicated genetic influences on borderline personality disorder (BPO) features, with a heritability estimate of 42%. To date, no genome-wide linkage study has been conducted to identify the genomic region(s) containing the quantitative trait loci that influence the manifestation of BPD features. Methods We conducted a family-based linkage study using Merlin regress. The participating families were drawn from the community-based Netherlands Twin Register. The sample consisted of 711 sibling pairs with phenotype and genotype data, and 561 additional parents with genotype data. BPD features were assessed on a quantitative scale. Results Evidence for linkage was found on chromosomes 1, 4, 9, and 18. The highest linkage peak was found on chromosome 9p at marker D9S286 with a logarithm of odds score of 3.548 (empirical P= 0.0001). Conclusion To our knowledge, this is the first linkage study on BPD features and shows that chromosome 9 is the richest candidate for genes influencing BPD. The results of this study will move the field closer to determining the genetic etiology of BPD and may have important implications for treatment programs in the future. Association studies in this region are, however, warranted to detect the actual genes. © 2008 Wolters Kluwer Health|Lippincott Williams & Wilkins.
Original languageEnglish
Pages (from-to)302-307
JournalPsychiatric Genetics
Volume18
Issue number6
DOIs
Publication statusPublished - 2008

Fingerprint

Chromosomes, Human, Pair 9
Borderline Personality Disorder
Neurofibromin 2
Genotype
Chromosomes, Human, Pair 4
Twin Studies
Chromosomes, Human, Pair 1
Quantitative Trait Loci
Netherlands
Genes
Chromosomes
Genome
Phenotype
Health

Cite this

@article{59097406ca414468b3fe6e020af2feae,
title = "Chromosome 9: linkage for borderline personality disorder features.",
abstract = "Objective A large-scale twin study implicated genetic influences on borderline personality disorder (BPO) features, with a heritability estimate of 42{\%}. To date, no genome-wide linkage study has been conducted to identify the genomic region(s) containing the quantitative trait loci that influence the manifestation of BPD features. Methods We conducted a family-based linkage study using Merlin regress. The participating families were drawn from the community-based Netherlands Twin Register. The sample consisted of 711 sibling pairs with phenotype and genotype data, and 561 additional parents with genotype data. BPD features were assessed on a quantitative scale. Results Evidence for linkage was found on chromosomes 1, 4, 9, and 18. The highest linkage peak was found on chromosome 9p at marker D9S286 with a logarithm of odds score of 3.548 (empirical P= 0.0001). Conclusion To our knowledge, this is the first linkage study on BPD features and shows that chromosome 9 is the richest candidate for genes influencing BPD. The results of this study will move the field closer to determining the genetic etiology of BPD and may have important implications for treatment programs in the future. Association studies in this region are, however, warranted to detect the actual genes. {\circledC} 2008 Wolters Kluwer Health|Lippincott Williams & Wilkins.",
author = "M.A. Distel and J.J. Hottenga and T.J. Trull and D.I. Boomsma",
year = "2008",
doi = "10.1097/YPG.0b013e3283118468",
language = "English",
volume = "18",
pages = "302--307",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

Chromosome 9: linkage for borderline personality disorder features. / Distel, M.A.; Hottenga, J.J.; Trull, T.J.; Boomsma, D.I.

In: Psychiatric Genetics, Vol. 18, No. 6, 2008, p. 302-307.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Chromosome 9: linkage for borderline personality disorder features.

AU - Distel, M.A.

AU - Hottenga, J.J.

AU - Trull, T.J.

AU - Boomsma, D.I.

PY - 2008

Y1 - 2008

N2 - Objective A large-scale twin study implicated genetic influences on borderline personality disorder (BPO) features, with a heritability estimate of 42%. To date, no genome-wide linkage study has been conducted to identify the genomic region(s) containing the quantitative trait loci that influence the manifestation of BPD features. Methods We conducted a family-based linkage study using Merlin regress. The participating families were drawn from the community-based Netherlands Twin Register. The sample consisted of 711 sibling pairs with phenotype and genotype data, and 561 additional parents with genotype data. BPD features were assessed on a quantitative scale. Results Evidence for linkage was found on chromosomes 1, 4, 9, and 18. The highest linkage peak was found on chromosome 9p at marker D9S286 with a logarithm of odds score of 3.548 (empirical P= 0.0001). Conclusion To our knowledge, this is the first linkage study on BPD features and shows that chromosome 9 is the richest candidate for genes influencing BPD. The results of this study will move the field closer to determining the genetic etiology of BPD and may have important implications for treatment programs in the future. Association studies in this region are, however, warranted to detect the actual genes. © 2008 Wolters Kluwer Health|Lippincott Williams & Wilkins.

AB - Objective A large-scale twin study implicated genetic influences on borderline personality disorder (BPO) features, with a heritability estimate of 42%. To date, no genome-wide linkage study has been conducted to identify the genomic region(s) containing the quantitative trait loci that influence the manifestation of BPD features. Methods We conducted a family-based linkage study using Merlin regress. The participating families were drawn from the community-based Netherlands Twin Register. The sample consisted of 711 sibling pairs with phenotype and genotype data, and 561 additional parents with genotype data. BPD features were assessed on a quantitative scale. Results Evidence for linkage was found on chromosomes 1, 4, 9, and 18. The highest linkage peak was found on chromosome 9p at marker D9S286 with a logarithm of odds score of 3.548 (empirical P= 0.0001). Conclusion To our knowledge, this is the first linkage study on BPD features and shows that chromosome 9 is the richest candidate for genes influencing BPD. The results of this study will move the field closer to determining the genetic etiology of BPD and may have important implications for treatment programs in the future. Association studies in this region are, however, warranted to detect the actual genes. © 2008 Wolters Kluwer Health|Lippincott Williams & Wilkins.

U2 - 10.1097/YPG.0b013e3283118468

DO - 10.1097/YPG.0b013e3283118468

M3 - Article

VL - 18

SP - 302

EP - 307

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 6

ER -