Chromosome organization in bacteria: mechanistic insights into genome structure and function

Remus T. Dame; Fatema-Zahra M. Rashid; David C. Grainger

doi:10.1038/s41576-019-0185-4

Chromosome organization in bacteria: mechanistic insights into genome structure and function

Remus T. Dame
, Fatema-Zahra M. Rashid
, David C. Grainger

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

Bacterial chromosomes are folded to compact DNA and facilitate cellular processes. Studying model bacteria has revealed aspects of chromosome folding that are applicable to many species. Primarily controlled by nucleoid-associated proteins, chromosome folding is hierarchical, from large-scale macrodomains to smaller-scale structures that influence DNA transactions, including replication and transcription. Here we review the environmentally regulated, architectural and regulatory roles of nucleoid-associated proteins and the implications for bacterial cell biology. We also highlight similarities and differences in the chromosome folding mechanisms of bacteria and eukaryotes.

Original language	English
Pages (from-to)	227-242
Journal	Nature Reviews Genetics
Volume	21
Issue number	4
DOIs	https://doi.org/10.1038/s41576-019-0185-4
Publication status	Published - 1 Apr 2020
Externally published	Yes

Funding

The authors thank the Netherlands Organization for Scientific Research (VICI 016.160.613) (R.T.D.), the Wellcome Trust (212193/Z/18/Z) (D.C.G.), the Leverhulme Trust (RPG-2018– 198) (D.C.G.), the UK Biotechnology and Biological Sciences Research Council (BB/H010289/1) (D.C.G.) and the Human Frontier Science Program (HFSP; RGP0014/2014) (R.T.D. and D.C.G.) for funding of current research in their laboratories.

Funders	Funder number
Netherlands Organization for Scientific Research
VICI
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	016.160.613
Leverhulme Trust	RPG-2018– 198
Biotechnology and Biological Sciences Research Council	BB/H010289/1
Wellcome Trust	212193, 212193/Z/18/Z
Human Frontier Science Program	RGP0014/2014

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abstract = "Bacterial chromosomes are folded to compact DNA and facilitate cellular processes. Studying model bacteria has revealed aspects of chromosome folding that are applicable to many species. Primarily controlled by nucleoid-associated proteins, chromosome folding is hierarchical, from large-scale macrodomains to smaller-scale structures that influence DNA transactions, including replication and transcription. Here we review the environmentally regulated, architectural and regulatory roles of nucleoid-associated proteins and the implications for bacterial cell biology. We also highlight similarities and differences in the chromosome folding mechanisms of bacteria and eukaryotes.",

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AU - Grainger, David C.

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AB - Bacterial chromosomes are folded to compact DNA and facilitate cellular processes. Studying model bacteria has revealed aspects of chromosome folding that are applicable to many species. Primarily controlled by nucleoid-associated proteins, chromosome folding is hierarchical, from large-scale macrodomains to smaller-scale structures that influence DNA transactions, including replication and transcription. Here we review the environmentally regulated, architectural and regulatory roles of nucleoid-associated proteins and the implications for bacterial cell biology. We also highlight similarities and differences in the chromosome folding mechanisms of bacteria and eukaryotes.

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Chromosome organization in bacteria: mechanistic insights into genome structure and function

Abstract

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