Chronic oral graft-versus-host disease: induction and maintenance therapy with photobiomodulation therapy

J.B. Epstein, J.E. Raber-Durlacher, G.L. Epstein, M.D. Hazenberg, D. Tzachanis, R.T. Spielberger

Research output: Contribution to JournalArticleAcademicpeer-review


Abstract: This study presents follow-up of a prior study of patients with chronic symptomatic oral chronic graft-versus-host-disease (cGVHD) managed with photobiomodulation therapy (PBM therapy for 1 month. Here, we report long-term follow-up of a series of patients where PBM therapy in patients with oral cGVHD for maintenance follows the initial period of PBM therapy for continuing management. Patients and methods: We report continuing follow-up of 7 cases of oral cGVHD that were treated with PBM therapy. PBM therapy was continued in these patients with the goal of determining the best management schedule of PBM to maintain or improve control of each patient’s symptoms and signs of oral cGVHD. Results: Oral sensitivity and mucosal changes of cGVHD were controlled with a continuing schedule of PBM therapy of up to 6–8-week treatment intervals in patients with continuing GVHD. These findings suggest that PBM therapy represents an additional approach for continuing management of oral cGVHD and that the frequency of treatment should be individualized for each patient to provide best control of oral findings. In one case weekly PBM treatment was continued, while in others, management on a monthly or bimonthly basis was associated with control of the oral condition. PBM may be individualized and provided based upon best control of the symptoms and signs of oral GVHD.

Original languageEnglish
Pages (from-to)1387-1394
Number of pages8
JournalSupportive Care in Cancer
Issue number3
Publication statusPublished - Mar 2021


The authors acknowledge James Carroll, THOR Photomedicine Ltd., for providing PBM therapy devices and suggestions on PBM therapy parameters used in this case series.

FundersFunder number
THOR Photomedicine Ltd.


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