Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects

Laura Bucci, Stella Lukas Yani, Cristina Fabbri, Astrid Y Bijlsma, Andrea B Maier, Carel G Meskers, Marco V Narici, David A Jones, Jamie S McPhee, Enn Seppet, Helena Gapeyeva, Mati Pääsuke, Sarianna Sipilä, Vuokko Kovanen, Lauri Stenroth, Antonio Musarò, Jean-Yves Hogrel, Yoann Barnouin, Gillian Butler-Browne, Miriam Capri & 2 others Claudio Franceschi, Stefano Salvioli

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

It is known that adipose tissue mass increases with age, and that a number of hormones, collectively called adipokines, are produced by adipose tissue. For most of them it is not known whether their plasmatic levels change with age. Moreover, it is known that adipose tissue infiltration in skeletal muscle is related to sarcopenia and loss of muscle strength. In this study we investigated the age-related changes of representative adipokines and insulin-like growth factor (IGF)-1 and their effect on muscle strength. We studied the association between circulating levels of adiponectin, leptin, resistin and IGF-1 and muscle strength. This cross-sectional study included 412 subjects of different age (152 subjects aged 18-30 years and 260 subjects aged 69-81 years) recruited within the framework of the European research network project "Myoage". The levels of adiponectin (both in male and female subjects) and leptin (only in males) were significantly higher in old subjects compared to young, while those of IGF-1 were lower in old subjects. In old subjects adiponectin, resistin and the resistin/IGF-1 ratio (but not IGF-1 alone) were inversely associated with quadriceps torque, while only adiponectin was inversely associated with handgrip strength independently from percentage of fat mass, height, age, gender and geographical origin. The ratio of leptin to adiponectin was directly associated with handgrip strength in both young and old subjects. These results suggest that in humans the age-associated loss of strength is associated with the levels of representative adipokines and IGF-1.

Original languageEnglish
Pages (from-to)261-72
Number of pages12
JournalBiogerontology
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 2013

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Adipokines
Muscle Strength
Somatomedins
Adiponectin
Healthy Volunteers
Skeletal Muscle
Resistin
Leptin
Adipose Tissue
Sarcopenia
Torque
Cross-Sectional Studies
Fats
Hormones
Research

Keywords

  • Adipokines/blood
  • Adiponectin/blood
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Cross-Sectional Studies
  • Female
  • Hand Strength/physiology
  • Humans
  • Insulin-Like Growth Factor I/metabolism
  • Leptin/blood
  • Male
  • Muscle Strength/physiology
  • Muscle, Skeletal/physiology
  • Resistin/blood
  • Signal Transduction/physiology
  • Young Adult

Cite this

Bucci, Laura ; Yani, Stella Lukas ; Fabbri, Cristina ; Bijlsma, Astrid Y ; Maier, Andrea B ; Meskers, Carel G ; Narici, Marco V ; Jones, David A ; McPhee, Jamie S ; Seppet, Enn ; Gapeyeva, Helena ; Pääsuke, Mati ; Sipilä, Sarianna ; Kovanen, Vuokko ; Stenroth, Lauri ; Musarò, Antonio ; Hogrel, Jean-Yves ; Barnouin, Yoann ; Butler-Browne, Gillian ; Capri, Miriam ; Franceschi, Claudio ; Salvioli, Stefano. / Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects. In: Biogerontology. 2013 ; Vol. 14, No. 3. pp. 261-72.
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title = "Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects",
abstract = "It is known that adipose tissue mass increases with age, and that a number of hormones, collectively called adipokines, are produced by adipose tissue. For most of them it is not known whether their plasmatic levels change with age. Moreover, it is known that adipose tissue infiltration in skeletal muscle is related to sarcopenia and loss of muscle strength. In this study we investigated the age-related changes of representative adipokines and insulin-like growth factor (IGF)-1 and their effect on muscle strength. We studied the association between circulating levels of adiponectin, leptin, resistin and IGF-1 and muscle strength. This cross-sectional study included 412 subjects of different age (152 subjects aged 18-30 years and 260 subjects aged 69-81 years) recruited within the framework of the European research network project {"}Myoage{"}. The levels of adiponectin (both in male and female subjects) and leptin (only in males) were significantly higher in old subjects compared to young, while those of IGF-1 were lower in old subjects. In old subjects adiponectin, resistin and the resistin/IGF-1 ratio (but not IGF-1 alone) were inversely associated with quadriceps torque, while only adiponectin was inversely associated with handgrip strength independently from percentage of fat mass, height, age, gender and geographical origin. The ratio of leptin to adiponectin was directly associated with handgrip strength in both young and old subjects. These results suggest that in humans the age-associated loss of strength is associated with the levels of representative adipokines and IGF-1.",
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author = "Laura Bucci and Yani, {Stella Lukas} and Cristina Fabbri and Bijlsma, {Astrid Y} and Maier, {Andrea B} and Meskers, {Carel G} and Narici, {Marco V} and Jones, {David A} and McPhee, {Jamie S} and Enn Seppet and Helena Gapeyeva and Mati P{\"a}{\"a}suke and Sarianna Sipil{\"a} and Vuokko Kovanen and Lauri Stenroth and Antonio Musar{\`o} and Jean-Yves Hogrel and Yoann Barnouin and Gillian Butler-Browne and Miriam Capri and Claudio Franceschi and Stefano Salvioli",
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doi = "10.1007/s10522-013-9428-5",
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pages = "261--72",
journal = "Biogerontology",
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Bucci, L, Yani, SL, Fabbri, C, Bijlsma, AY, Maier, AB, Meskers, CG, Narici, MV, Jones, DA, McPhee, JS, Seppet, E, Gapeyeva, H, Pääsuke, M, Sipilä, S, Kovanen, V, Stenroth, L, Musarò, A, Hogrel, J-Y, Barnouin, Y, Butler-Browne, G, Capri, M, Franceschi, C & Salvioli, S 2013, 'Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects' Biogerontology, vol. 14, no. 3, pp. 261-72. https://doi.org/10.1007/s10522-013-9428-5

Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects. / Bucci, Laura; Yani, Stella Lukas; Fabbri, Cristina; Bijlsma, Astrid Y; Maier, Andrea B; Meskers, Carel G; Narici, Marco V; Jones, David A; McPhee, Jamie S; Seppet, Enn; Gapeyeva, Helena; Pääsuke, Mati; Sipilä, Sarianna; Kovanen, Vuokko; Stenroth, Lauri; Musarò, Antonio; Hogrel, Jean-Yves; Barnouin, Yoann; Butler-Browne, Gillian; Capri, Miriam; Franceschi, Claudio; Salvioli, Stefano.

In: Biogerontology, Vol. 14, No. 3, 06.2013, p. 261-72.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects

AU - Bucci, Laura

AU - Yani, Stella Lukas

AU - Fabbri, Cristina

AU - Bijlsma, Astrid Y

AU - Maier, Andrea B

AU - Meskers, Carel G

AU - Narici, Marco V

AU - Jones, David A

AU - McPhee, Jamie S

AU - Seppet, Enn

AU - Gapeyeva, Helena

AU - Pääsuke, Mati

AU - Sipilä, Sarianna

AU - Kovanen, Vuokko

AU - Stenroth, Lauri

AU - Musarò, Antonio

AU - Hogrel, Jean-Yves

AU - Barnouin, Yoann

AU - Butler-Browne, Gillian

AU - Capri, Miriam

AU - Franceschi, Claudio

AU - Salvioli, Stefano

PY - 2013/6

Y1 - 2013/6

N2 - It is known that adipose tissue mass increases with age, and that a number of hormones, collectively called adipokines, are produced by adipose tissue. For most of them it is not known whether their plasmatic levels change with age. Moreover, it is known that adipose tissue infiltration in skeletal muscle is related to sarcopenia and loss of muscle strength. In this study we investigated the age-related changes of representative adipokines and insulin-like growth factor (IGF)-1 and their effect on muscle strength. We studied the association between circulating levels of adiponectin, leptin, resistin and IGF-1 and muscle strength. This cross-sectional study included 412 subjects of different age (152 subjects aged 18-30 years and 260 subjects aged 69-81 years) recruited within the framework of the European research network project "Myoage". The levels of adiponectin (both in male and female subjects) and leptin (only in males) were significantly higher in old subjects compared to young, while those of IGF-1 were lower in old subjects. In old subjects adiponectin, resistin and the resistin/IGF-1 ratio (but not IGF-1 alone) were inversely associated with quadriceps torque, while only adiponectin was inversely associated with handgrip strength independently from percentage of fat mass, height, age, gender and geographical origin. The ratio of leptin to adiponectin was directly associated with handgrip strength in both young and old subjects. These results suggest that in humans the age-associated loss of strength is associated with the levels of representative adipokines and IGF-1.

AB - It is known that adipose tissue mass increases with age, and that a number of hormones, collectively called adipokines, are produced by adipose tissue. For most of them it is not known whether their plasmatic levels change with age. Moreover, it is known that adipose tissue infiltration in skeletal muscle is related to sarcopenia and loss of muscle strength. In this study we investigated the age-related changes of representative adipokines and insulin-like growth factor (IGF)-1 and their effect on muscle strength. We studied the association between circulating levels of adiponectin, leptin, resistin and IGF-1 and muscle strength. This cross-sectional study included 412 subjects of different age (152 subjects aged 18-30 years and 260 subjects aged 69-81 years) recruited within the framework of the European research network project "Myoage". The levels of adiponectin (both in male and female subjects) and leptin (only in males) were significantly higher in old subjects compared to young, while those of IGF-1 were lower in old subjects. In old subjects adiponectin, resistin and the resistin/IGF-1 ratio (but not IGF-1 alone) were inversely associated with quadriceps torque, while only adiponectin was inversely associated with handgrip strength independently from percentage of fat mass, height, age, gender and geographical origin. The ratio of leptin to adiponectin was directly associated with handgrip strength in both young and old subjects. These results suggest that in humans the age-associated loss of strength is associated with the levels of representative adipokines and IGF-1.

KW - Adipokines/blood

KW - Adiponectin/blood

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging/physiology

KW - Cross-Sectional Studies

KW - Female

KW - Hand Strength/physiology

KW - Humans

KW - Insulin-Like Growth Factor I/metabolism

KW - Leptin/blood

KW - Male

KW - Muscle Strength/physiology

KW - Muscle, Skeletal/physiology

KW - Resistin/blood

KW - Signal Transduction/physiology

KW - Young Adult

U2 - 10.1007/s10522-013-9428-5

DO - 10.1007/s10522-013-9428-5

M3 - Article

VL - 14

SP - 261

EP - 272

JO - Biogerontology

JF - Biogerontology

SN - 1389-5729

IS - 3

ER -