Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort

M. van der Esch; J. Knoop; M. van der Leeden; L.D. Roorda; W.F. Lems; D.L. Knol; J. Dekker

doi:10.1016/j.joca.2015.01.006

Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort

M. van der Esch
, J. Knoop
, M. van der Leeden
, L.D. Roorda
, W.F. Lems
, D.L. Knol
, J. Dekker

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To identify and validate previously established phenotypes of knee osteoarthritis (OA) based on similarities in clinical patient characteristics.

METHODS: Knee OA patients (N = 551) from the Amsterdam OA (AMS-OA) cohort provided data. Four clinical patient characteristics were assessed: upper leg muscle strength, body mass index (BMI), radiographic severity (Kellgren/Lawrence [KL] grade), and depressive mood (the Hospital Anxiety and Depression Scale [HADS] questionnaire). Cluster analysis was performed to identify the optimal number of phenotypes. Differences in clinical characteristics between the phenotypes were analyzed with ANOVA.

RESULTS: Cluster analysis identified five phenotypes of knee OA patients: "minimal joint disease phenotype", "strong muscle strength phenotype", "severe radiographic OA phenotype", "obese phenotype", and "depressive mood phenotype".

CONCLUSIONS: Among patients with knee OA, five phenotypes were identified based on four clinical characteristics. To a high degree, the results are a replication of earlier findings in the OA Initiative, indicating that these five phenotypes seem a stable, valid, and clinically relevant finding.

Original language	English
Pages (from-to)	544-549
Number of pages	6
Journal	Osteoarthritis and Cartilage
Volume	23
Issue number	4
Early online date	14 Jan 2015
DOIs	https://doi.org/10.1016/j.joca.2015.01.006
Publication status	Published - Apr 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aged
Body Mass Index
Cluster Analysis
Cohort Studies
Comorbidity
Cross-Sectional Studies
Depression/psychology
Female
Humans
Knee Joint/diagnostic imaging
Male
Middle Aged
Muscle Strength/physiology
Netherlands
Obesity/complications
Osteoarthritis, Knee/classification
Phenotype
Radiography
Reproducibility of Results
Severity of Illness Index
Surveys and Questionnaires

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10.1016/j.joca.2015.01.006

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title = "Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort",

abstract = "OBJECTIVE: To identify and validate previously established phenotypes of knee osteoarthritis (OA) based on similarities in clinical patient characteristics.METHODS: Knee OA patients (N = 551) from the Amsterdam OA (AMS-OA) cohort provided data. Four clinical patient characteristics were assessed: upper leg muscle strength, body mass index (BMI), radiographic severity (Kellgren/Lawrence [KL] grade), and depressive mood (the Hospital Anxiety and Depression Scale [HADS] questionnaire). Cluster analysis was performed to identify the optimal number of phenotypes. Differences in clinical characteristics between the phenotypes were analyzed with ANOVA.RESULTS: Cluster analysis identified five phenotypes of knee OA patients: {"}minimal joint disease phenotype{"}, {"}strong muscle strength phenotype{"}, {"}severe radiographic OA phenotype{"}, {"}obese phenotype{"}, and {"}depressive mood phenotype{"}.CONCLUSIONS: Among patients with knee OA, five phenotypes were identified based on four clinical characteristics. To a high degree, the results are a replication of earlier findings in the OA Initiative, indicating that these five phenotypes seem a stable, valid, and clinically relevant finding.",

keywords = "Aged, Body Mass Index, Cluster Analysis, Cohort Studies, Comorbidity, Cross-Sectional Studies, Depression/psychology, Female, Humans, Knee Joint/diagnostic imaging, Male, Middle Aged, Muscle Strength/physiology, Netherlands, Obesity/complications, Osteoarthritis, Knee/classification, Phenotype, Radiography, Reproducibility of Results, Severity of Illness Index, Surveys and Questionnaires",

author = "\{van der Esch\}, M. and J. Knoop and \{van der Leeden\}, M. and L.D. Roorda and W.F. Lems and D.L. Knol and J. Dekker",

year = "2015",

month = apr,

doi = "10.1016/j.joca.2015.01.006",

language = "English",

volume = "23",

pages = "544--549",

journal = "Osteoarthritis and Cartilage",

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publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - Clinical phenotypes in patients with knee osteoarthritis

T2 - a study in the Amsterdam osteoarthritis cohort

AU - van der Esch, M.

AU - Knoop, J.

AU - van der Leeden, M.

AU - Roorda, L.D.

AU - Lems, W.F.

AU - Knol, D.L.

AU - Dekker, J.

PY - 2015/4

Y1 - 2015/4

N2 - OBJECTIVE: To identify and validate previously established phenotypes of knee osteoarthritis (OA) based on similarities in clinical patient characteristics.METHODS: Knee OA patients (N = 551) from the Amsterdam OA (AMS-OA) cohort provided data. Four clinical patient characteristics were assessed: upper leg muscle strength, body mass index (BMI), radiographic severity (Kellgren/Lawrence [KL] grade), and depressive mood (the Hospital Anxiety and Depression Scale [HADS] questionnaire). Cluster analysis was performed to identify the optimal number of phenotypes. Differences in clinical characteristics between the phenotypes were analyzed with ANOVA.RESULTS: Cluster analysis identified five phenotypes of knee OA patients: "minimal joint disease phenotype", "strong muscle strength phenotype", "severe radiographic OA phenotype", "obese phenotype", and "depressive mood phenotype".CONCLUSIONS: Among patients with knee OA, five phenotypes were identified based on four clinical characteristics. To a high degree, the results are a replication of earlier findings in the OA Initiative, indicating that these five phenotypes seem a stable, valid, and clinically relevant finding.

AB - OBJECTIVE: To identify and validate previously established phenotypes of knee osteoarthritis (OA) based on similarities in clinical patient characteristics.METHODS: Knee OA patients (N = 551) from the Amsterdam OA (AMS-OA) cohort provided data. Four clinical patient characteristics were assessed: upper leg muscle strength, body mass index (BMI), radiographic severity (Kellgren/Lawrence [KL] grade), and depressive mood (the Hospital Anxiety and Depression Scale [HADS] questionnaire). Cluster analysis was performed to identify the optimal number of phenotypes. Differences in clinical characteristics between the phenotypes were analyzed with ANOVA.RESULTS: Cluster analysis identified five phenotypes of knee OA patients: "minimal joint disease phenotype", "strong muscle strength phenotype", "severe radiographic OA phenotype", "obese phenotype", and "depressive mood phenotype".CONCLUSIONS: Among patients with knee OA, five phenotypes were identified based on four clinical characteristics. To a high degree, the results are a replication of earlier findings in the OA Initiative, indicating that these five phenotypes seem a stable, valid, and clinically relevant finding.

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KW - Cross-Sectional Studies

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KW - Humans

KW - Knee Joint/diagnostic imaging

KW - Male

KW - Middle Aged

KW - Muscle Strength/physiology

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KW - Obesity/complications

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KW - Phenotype

KW - Radiography

KW - Reproducibility of Results

KW - Severity of Illness Index

KW - Surveys and Questionnaires

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JO - Osteoarthritis and Cartilage

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ER -

Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort

Abstract

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Keywords

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