Clinical Studies on Jaw Bone Regeneration: Application of Autologous Bone Grafts, Bone Substitutes, and Adipose Stem Cells

In this thesis, we investigated bone formation and vascularization in jaw bone regeneration using different bone grafting materials, either or not supplemented with SVF, for dental implant placement. MSFE was used as a human experimental model for the application of different bone grafting materials. MSFE was also used as a human split-mouth model to compare the application of SVF-supplemented calcium phosphate bone substitute with calcium phosphate bone substitute only in jaw bone regeneration. The clinical studies in this thesis have contributed to new insights in bone formation and vascularization in jaw bone regeneration using different bone grafting materials, either or not supplemented with SVF, for dental implant placement. SVF-supplementation increased vascularization and osteoid volume in calcium phosphate bone substitute to a similar level of using retromolar bone graft in patients who had undergone MSFE. Therefore, SVF-supplementation might accelerate dental implant placement and loading. The successful 10-year clinical and radiological follow-up of patients treated with MSFE using SVF-supplemented calcium phosphate bone substitute, provides powerful leads to extent the clinical application of SVF. The new insights provided in this thesis could have important implications for the development of new strategies in cellular bone tissue engineering in the fields of oral and maxillofacial surgery and orthopedics.