Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease

W. Jongbloed; K.D. van Dijk; S.D. Mulder; W.D.J. van de Berg; M.A. Blankenstein; W.M. van der Flier; R. Veerhuis

doi:10.3233/JAD-150036

Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease

W. Jongbloed, K.D. van Dijk, S.D. Mulder, W.D.J. van de Berg, M.A. Blankenstein, W.M. van der Flier, R. Veerhuis

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ

Original language	English
Pages (from-to)	1103-1110
Journal	Journal of Alzheimer's Disease
Volume	46
Issue number	4
DOIs	https://doi.org/10.3233/JAD-150036
Publication status	Published - 2015

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title = "Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease",

abstract = "Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ",

author = "W. Jongbloed and {van Dijk}, K.D. and S.D. Mulder and {van de Berg}, W.D.J. and M.A. Blankenstein and {van der Flier}, W.M. and R. Veerhuis",

year = "2015",

doi = "10.3233/JAD-150036",

language = "English",

volume = "46",

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journal = "Journal of Alzheimer's Disease",

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T1 - Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease

AU - Jongbloed, W.

AU - van Dijk, K.D.

AU - Mulder, S.D.

AU - van de Berg, W.D.J.

AU - Blankenstein, M.A.

AU - van der Flier, W.M.

AU - Veerhuis, R.

PY - 2015

Y1 - 2015

N2 - Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ

AB - Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ

U2 - 10.3233/JAD-150036

DO - 10.3233/JAD-150036

M3 - Article

VL - 46

SP - 1103

EP - 1110

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 4

ER -

Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease

Abstract

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