Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease

W. Jongbloed; K.D. van Dijk; S.D. Mulder; W.D.J. van de Berg; M.A. Blankenstein; W.M. van der Flier; R. Veerhuis

doi:10.3233/JAD-150036

Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease

W. Jongbloed
, K.D. van Dijk
, S.D. Mulder
, W.D.J. van de Berg
, M.A. Blankenstein
, W.M. van der Flier
, R. Veerhuis

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ

Original language	English
Pages (from-to)	1103-1110
Journal	Journal of Alzheimer's Disease
Volume	46
Issue number	4
DOIs	https://doi.org/10.3233/JAD-150036
Publication status	Published - 2015

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SDG 3 Good Health and Well-being

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10.3233/JAD-150036

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title = "Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease",

abstract = "Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ",

author = "W. Jongbloed and \{van Dijk\}, K.D. and S.D. Mulder and \{van de Berg\}, W.D.J. and M.A. Blankenstein and \{van der Flier\}, W.M. and R. Veerhuis",

year = "2015",

doi = "10.3233/JAD-150036",

language = "English",

volume = "46",

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journal = "Journal of Alzheimer's Disease",

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T1 - Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease

AU - Jongbloed, W.

AU - van Dijk, K.D.

AU - Mulder, S.D.

AU - van de Berg, W.D.J.

AU - Blankenstein, M.A.

AU - van der Flier, W.M.

AU - Veerhuis, R.

PY - 2015

Y1 - 2015

N2 - Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ

AB - Background: Increased clusterin levels have been reported in brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients. Because changes are also observed in mild cognitive impairment (MCI), a possible relationship between clusterin levels and early neurodegenerative changes in AD was suggested. Objectives: To determine whether clusterin concentrations could 1) serve as a diagnostic marker for AD, 2) predict disease progression in MCI, and 3) correlate with AD-biomarkers. Methods: Clusterin levels in CSF and plasma, as well as AD biomarker levels of Aβ

U2 - 10.3233/JAD-150036

DO - 10.3233/JAD-150036

M3 - Article

SN - 1387-2877

VL - 46

SP - 1103

EP - 1110

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 4

ER -

Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease

Abstract

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