Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression

A.L. Beem, E.J.C. de Geus, J.J. Hottenga, P.F. Sullivan, G. Willemsen, P.E. Slagboom, D.I. Boomsma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, depression and neuroticism in a Dutch sample of 347 males and 448 females, and to DSM-IV major depression in a subsample of 210 males and 295 females. The association of the 124-bp allele to depression in females was not replicated, but there were significant associations (not significant after correction for multiple testing) with anxiety and anxious depression in males. However, the association occurred in the absence of evidence for linkage in this region on chromosome 2. © 2006 Springer Science+Business Media, Inc.
Original languageEnglish
Pages (from-to)127-136
JournalBehavior Genetics
Volume36
Issue number1
DOIs
Publication statusPublished - 2006

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anxiety
linkage (genetics)
allele
Anxiety
Alleles
Depression
alleles
Psychiatry
Chromosomes, Human, Pair 2
chromosome
Diagnostic and Statistical Manual of Mental Disorders
chromosomes
Neuroticism
marker
testing
sampling

Cite this

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title = "Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression",
abstract = "A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, depression and neuroticism in a Dutch sample of 347 males and 448 females, and to DSM-IV major depression in a subsample of 210 males and 295 females. The association of the 124-bp allele to depression in females was not replicated, but there were significant associations (not significant after correction for multiple testing) with anxiety and anxious depression in males. However, the association occurred in the absence of evidence for linkage in this region on chromosome 2. {\circledC} 2006 Springer Science+Business Media, Inc.",
author = "A.L. Beem and {de Geus}, E.J.C. and J.J. Hottenga and P.F. Sullivan and G. Willemsen and P.E. Slagboom and D.I. Boomsma",
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language = "English",
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Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression. / Beem, A.L.; de Geus, E.J.C.; Hottenga, J.J.; Sullivan, P.F.; Willemsen, G.; Slagboom, P.E.; Boomsma, D.I.

In: Behavior Genetics, Vol. 36, No. 1, 2006, p. 127-136.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

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AU - de Geus, E.J.C.

AU - Hottenga, J.J.

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AU - Boomsma, D.I.

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AB - A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, depression and neuroticism in a Dutch sample of 347 males and 448 females, and to DSM-IV major depression in a subsample of 210 males and 295 females. The association of the 124-bp allele to depression in females was not replicated, but there were significant associations (not significant after correction for multiple testing) with anxiety and anxious depression in males. However, the association occurred in the absence of evidence for linkage in this region on chromosome 2. © 2006 Springer Science+Business Media, Inc.

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