Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)

Fabio Feroldi; Margherita Vaselli; Mariska Verlaan; Helene Knaus; Valentina Davidoiu; Danielle Vugts; Carla Molthoff; Guus van Dongen; Johannes F. de Boer

doi:10.1117/12.2545222

Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)

Fabio Feroldi, Margherita Vaselli, Mariska Verlaan, Helene Knaus, Valentina Davidoiu, Danielle Vugts, Carla Molthoff, Guus van Dongen, Johannes F. de Boer

Research output: Contribution to Conference › Paper › Academic

Abstract

Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission tomography, this feat is currently not achievable. Here, we demonstrate that revealing the TME is possible with immuno-near-infrared-fluorescence (Immuno-NIRF) imaging. Moreover, we combined immuno-NIRF with optical coherence tomography (OCT) to provide structural context to the molecular images. The combination of the two techniques may represent a novel tool in the operating room for assessing development or early diagnosis of tumors.

Original language	English
Number of pages	11222
DOIs	https://doi.org/10.1117/12.2545222
Publication status	Published - 10 Mar 2020
Event	SPIE BiOS 2020 - Online, San Francisco, United States Duration: 1 Feb 2020 → 6 Feb 2020

Conference

Conference	SPIE BiOS 2020
Country/Territory	United States
City	San Francisco
Period	1/02/20 → 6/02/20

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.2545222

Persistent URL (handle)

Copy link address

Cite this

@conference{de0789e322974629bb5d107e4ab33820,

title = "Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)",

abstract = "Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission tomography, this feat is currently not achievable. Here, we demonstrate that revealing the TME is possible with immuno-near-infrared-fluorescence (Immuno-NIRF) imaging. Moreover, we combined immuno-NIRF with optical coherence tomography (OCT) to provide structural context to the molecular images. The combination of the two techniques may represent a novel tool in the operating room for assessing development or early diagnosis of tumors.",

author = "Fabio Feroldi and Margherita Vaselli and Mariska Verlaan and Helene Knaus and Valentina Davidoiu and Danielle Vugts and Carla Molthoff and {van Dongen}, Guus and {de Boer}, {Johannes F.}",

year = "2020",

month = mar,

day = "10",

doi = "10.1117/12.2545222",

language = "English",

note = "SPIE BiOS 2020 ; Conference date: 01-02-2020 Through 06-02-2020",

}

Feroldi, F, Vaselli, M, Verlaan, M, Knaus, H, Davidoiu, V, Vugts, D, Molthoff, C, van Dongen, G & de Boer, JF 2020, 'Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)', Paper presented at SPIE BiOS 2020, San Francisco, United States, 1/02/20 - 6/02/20. https://doi.org/10.1117/12.2545222

TY - CONF

T1 - Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)

AU - Feroldi, Fabio

AU - Vaselli, Margherita

AU - Verlaan, Mariska

AU - Knaus, Helene

AU - Davidoiu, Valentina

AU - Vugts, Danielle

AU - Molthoff, Carla

AU - van Dongen, Guus

AU - de Boer, Johannes F.

PY - 2020/3/10

Y1 - 2020/3/10

N2 - Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission tomography, this feat is currently not achievable. Here, we demonstrate that revealing the TME is possible with immuno-near-infrared-fluorescence (Immuno-NIRF) imaging. Moreover, we combined immuno-NIRF with optical coherence tomography (OCT) to provide structural context to the molecular images. The combination of the two techniques may represent a novel tool in the operating room for assessing development or early diagnosis of tumors.

AB - Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission tomography, this feat is currently not achievable. Here, we demonstrate that revealing the TME is possible with immuno-near-infrared-fluorescence (Immuno-NIRF) imaging. Moreover, we combined immuno-NIRF with optical coherence tomography (OCT) to provide structural context to the molecular images. The combination of the two techniques may represent a novel tool in the operating room for assessing development or early diagnosis of tumors.

UR - https://www.mendeley.com/catalogue/34bbf86f-00b9-3b1e-9baf-dee2fbff095d/

U2 - 10.1117/12.2545222

DO - 10.1117/12.2545222

M3 - Paper

T2 - SPIE BiOS 2020

Y2 - 1 February 2020 through 6 February 2020

ER -

Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation)

Abstract

Conference

UN SDGs

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this