Common variants at 12q14 and 12q24 are associated with hippocampal volume

J.C. Bis, C.S. DeCarli, A. Vernon Smith, F. van der Lijn, F. Crivello, M. Fornage, S. Debette, J.M. Shulman, H. Schmidt, V. Srikanth, M. Schuur, L. Yu, S. Choi, S. Sigurdsson, B.F.J. Verhaaren, A.L. DeStefano, J.C. Lambert, C.R., Jr. Jack, M. Struchalin, J. StankovichC.A. Ibrahim-Verbaas, D. Fleischman, A. Zijdenbos, T. den Heijer, B. Mazoyer, L.H. Coker, C. Enzinger, P. Danoy, N. Amin, K. Arfanakis, M.A. van Buchem, R.F.A.G. de Bruijn, A. Beiser, C. Dufouil, J. Huang, M. Cavalieri, R. Thomson, W.J. Niessen, L.B. Chibnik, G.K. Gislason, A. Hofman, A. Pikula, P. Amouyel, K.B. Freeman, T.G. Phan, B.A. Oostra, J.L. Stein, S.E. Medland, A.A. Vasquez, D.P. Hibar, M.J. Wright, B. Franke, N.G. Martin, P.M. Thompson, J.J. Hottenga, D.I. Boomsma, M.A. Nalls, A.G. Uitterlinden, R. Au, A. Elbaz, R.J. Beare, J.C. van Swieten, O.L. Lopez, T.B. Harris, V. Chouraki, M.M.B. Breteler, P.L. de Jager, J.T. Becker, M.W. Vernooij, D. Knopman, F. Fazekas, P.A. Wolf, A. van der Lugt, V. Gudnason, Jr. W.T. Longstreth, M.A. Brown, D.A. Bennett, C.M. van Duijn, T.H. Mosley, R. Schmidt, C. Tzourio, L.J. Launer, M. Arfan Ikram, S. Seshadri

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10
Original languageEnglish
Pages (from-to)545-551
JournalNature Genetics
Volume44
Issue number5
DOIs
Publication statusPublished - 2012

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