Common variants at 12q14 and 12q24 are associated with hippocampal volume

J.C. Bis; C.S. DeCarli; A. Vernon Smith; F. van der Lijn; F. Crivello; M. Fornage; S. Debette; J.M. Shulman; H. Schmidt; V. Srikanth; M. Schuur; L. Yu; S. Choi; S. Sigurdsson; B.F.J. Verhaaren; A.L. DeStefano; J.C. Lambert; C.R., Jr. Jack; M. Struchalin; J. Stankovich; C.A. Ibrahim-Verbaas; D. Fleischman; A. Zijdenbos; T. den Heijer; B. Mazoyer; L.H. Coker; C. Enzinger; P. Danoy; N. Amin; K. Arfanakis; M.A. van Buchem; R.F.A.G. de Bruijn; A. Beiser; C. Dufouil; J. Huang; M. Cavalieri; R. Thomson; W.J. Niessen; L.B. Chibnik; G.K. Gislason; A. Hofman; A. Pikula; P. Amouyel; K.B. Freeman; T.G. Phan; B.A. Oostra; J.L. Stein; S.E. Medland; A.A. Vasquez; D.P. Hibar; M.J. Wright; B. Franke; N.G. Martin; P.M. Thompson; J.J. Hottenga; D.I. Boomsma; M.A. Nalls; A.G. Uitterlinden; R. Au; A. Elbaz; R.J. Beare; J.C. van Swieten; O.L. Lopez; T.B. Harris; V. Chouraki; M.M.B. Breteler; P.L. de Jager; J.T. Becker; M.W. Vernooij; D. Knopman; F. Fazekas; P.A. Wolf; A. van der Lugt; V. Gudnason; Jr. W.T. Longstreth; M.A. Brown; D.A. Bennett; C.M. van Duijn; T.H. Mosley; R. Schmidt; C. Tzourio; L.J. Launer; M. Arfan Ikram; S. Seshadri

doi:10.1038/ng.2237

Common variants at 12q14 and 12q24 are associated with hippocampal volume

J.C. Bis
, C.S. DeCarli
, A. Vernon Smith
, F. van der Lijn
, F. Crivello
, M. Fornage
, S. Debette
, J.M. Shulman
, H. Schmidt
, V. Srikanth
, M. Schuur
, L. Yu
, S. Choi
, S. Sigurdsson
, B.F.J. Verhaaren
, A.L. DeStefano
, J.C. Lambert
, C.R., Jr. Jack
, M. Struchalin
, J. Stankovich

C.A. Ibrahim-Verbaas, D. Fleischman, A. Zijdenbos, T. den Heijer, B. Mazoyer, L.H. Coker, C. Enzinger, P. Danoy, N. Amin, K. Arfanakis, M.A. van Buchem, R.F.A.G. de Bruijn, A. Beiser, C. Dufouil, J. Huang, M. Cavalieri, R. Thomson, W.J. Niessen, L.B. Chibnik, G.K. Gislason, A. Hofman, A. Pikula, P. Amouyel, K.B. Freeman, T.G. Phan, B.A. Oostra, J.L. Stein, S.E. Medland, A.A. Vasquez, D.P. Hibar, M.J. Wright, B. Franke, N.G. Martin, P.M. Thompson, J.J. Hottenga, D.I. Boomsma, M.A. Nalls, A.G. Uitterlinden, R. Au, A. Elbaz, R.J. Beare, J.C. van Swieten, O.L. Lopez, T.B. Harris, V. Chouraki, M.M.B. Breteler, P.L. de Jager, J.T. Becker, M.W. Vernooij, D. Knopman, F. Fazekas, P.A. Wolf, A. van der Lugt, V. Gudnason, Jr. W.T. Longstreth, M.A. Brown, D.A. Bennett, C.M. van Duijn, T.H. Mosley, R. Schmidt, C. Tzourio, L.J. Launer, M. Arfan Ikram, S. Seshadri

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10

Original language	English
Pages (from-to)	545-551
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2237
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cohort Studies

Netherlands Twin Register (NTR)

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10.1038/ng.2237

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Bis, J. C., DeCarli, C. S., Vernon Smith, A., van der Lijn, F., Crivello, F., Fornage, M., Debette, S., Shulman, J. M., Schmidt, H., Srikanth, V., Schuur, M., Yu, L., Choi, S., Sigurdsson, S., Verhaaren, B. F. J., DeStefano, A. L., Lambert, J. C., Jack, C. R. . J., Struchalin, M., ... Seshadri, S. (2012). Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nature Genetics, 44(5), 545-551. https://doi.org/10.1038/ng.2237

@article{589f404420c143aa8b681e746f02e1ef,

title = "Common variants at 12q14 and 12q24 are associated with hippocampal volume",

abstract = "Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10",

author = "J.C. Bis and C.S. DeCarli and \{Vernon Smith\}, A. and \{van der Lijn\}, F. and F. Crivello and M. Fornage and S. Debette and J.M. Shulman and H. Schmidt and V. Srikanth and M. Schuur and L. Yu and S. Choi and S. Sigurdsson and B.F.J. Verhaaren and A.L. DeStefano and J.C. Lambert and Jack, \{C.R., Jr.\} and M. Struchalin and J. Stankovich and C.A. Ibrahim-Verbaas and D. Fleischman and A. Zijdenbos and \{den Heijer\}, T. and B. Mazoyer and L.H. Coker and C. Enzinger and P. Danoy and N. Amin and K. Arfanakis and \{van Buchem\}, M.A. and \{de Bruijn\}, R.F.A.G. and A. Beiser and C. Dufouil and J. Huang and M. Cavalieri and R. Thomson and W.J. Niessen and L.B. Chibnik and G.K. Gislason and A. Hofman and A. Pikula and P. Amouyel and K.B. Freeman and T.G. Phan and B.A. Oostra and J.L. Stein and S.E. Medland and A.A. Vasquez and D.P. Hibar and M.J. Wright and B. Franke and N.G. Martin and P.M. Thompson and J.J. Hottenga and D.I. Boomsma and M.A. Nalls and A.G. Uitterlinden and R. Au and A. Elbaz and R.J. Beare and \{van Swieten\}, J.C. and O.L. Lopez and T.B. Harris and V. Chouraki and M.M.B. Breteler and \{de Jager\}, P.L. and J.T. Becker and M.W. Vernooij and D. Knopman and F. Fazekas and P.A. Wolf and \{van der Lugt\}, A. and V. Gudnason and Longstreth, \{Jr. W.T.\} and M.A. Brown and D.A. Bennett and \{van Duijn\}, C.M. and T.H. Mosley and R. Schmidt and C. Tzourio and L.J. Launer and \{Arfan Ikram\}, M. and S. Seshadri",

year = "2012",

doi = "10.1038/ng.2237",

language = "English",

volume = "44",

pages = "545--551",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "5",

}

Bis, JC, DeCarli, CS, Vernon Smith, A, van der Lijn, F, Crivello, F, Fornage, M, Debette, S, Shulman, JM, Schmidt, H, Srikanth, V, Schuur, M, Yu, L, Choi, S, Sigurdsson, S, Verhaaren, BFJ, DeStefano, AL, Lambert, JC, Jack, CRJ, Struchalin, M, Stankovich, J, Ibrahim-Verbaas, CA, Fleischman, D, Zijdenbos, A, den Heijer, T, Mazoyer, B, Coker, LH, Enzinger, C, Danoy, P, Amin, N, Arfanakis, K, van Buchem, MA, de Bruijn, RFAG, Beiser, A, Dufouil, C, Huang, J, Cavalieri, M, Thomson, R, Niessen, WJ, Chibnik, LB, Gislason, GK, Hofman, A, Pikula, A, Amouyel, P, Freeman, KB, Phan, TG, Oostra, BA, Stein, JL, Medland, SE, Vasquez, AA, Hibar, DP, Wright, MJ, Franke, B, Martin, NG, Thompson, PM, Hottenga, JJ, Boomsma, DI, Nalls, MA, Uitterlinden, AG, Au, R, Elbaz, A, Beare, RJ, van Swieten, JC, Lopez, OL, Harris, TB, Chouraki, V, Breteler, MMB, de Jager, PL, Becker, JT, Vernooij, MW, Knopman, D, Fazekas, F, Wolf, PA, van der Lugt, A, Gudnason, V, Longstreth, JWT, Brown, MA, Bennett, DA, van Duijn, CM, Mosley, TH, Schmidt, R, Tzourio, C, Launer, LJ, Arfan Ikram, M & Seshadri, S 2012, 'Common variants at 12q14 and 12q24 are associated with hippocampal volume', Nature Genetics, vol. 44, no. 5, pp. 545-551. https://doi.org/10.1038/ng.2237

TY - JOUR

T1 - Common variants at 12q14 and 12q24 are associated with hippocampal volume

AU - Bis, J.C.

AU - DeCarli, C.S.

AU - Vernon Smith, A.

AU - van der Lijn, F.

AU - Crivello, F.

AU - Fornage, M.

AU - Debette, S.

AU - Shulman, J.M.

AU - Schmidt, H.

AU - Srikanth, V.

AU - Schuur, M.

AU - Yu, L.

AU - Choi, S.

AU - Sigurdsson, S.

AU - Verhaaren, B.F.J.

AU - DeStefano, A.L.

AU - Lambert, J.C.

AU - Jack, C.R., Jr.

AU - Struchalin, M.

AU - Stankovich, J.

AU - Ibrahim-Verbaas, C.A.

AU - Fleischman, D.

AU - Zijdenbos, A.

AU - den Heijer, T.

AU - Mazoyer, B.

AU - Coker, L.H.

AU - Enzinger, C.

AU - Danoy, P.

AU - Amin, N.

AU - Arfanakis, K.

AU - van Buchem, M.A.

AU - de Bruijn, R.F.A.G.

AU - Beiser, A.

AU - Dufouil, C.

AU - Huang, J.

AU - Cavalieri, M.

AU - Thomson, R.

AU - Niessen, W.J.

AU - Chibnik, L.B.

AU - Gislason, G.K.

AU - Hofman, A.

AU - Pikula, A.

AU - Amouyel, P.

AU - Freeman, K.B.

AU - Phan, T.G.

AU - Oostra, B.A.

AU - Stein, J.L.

AU - Medland, S.E.

AU - Vasquez, A.A.

AU - Hibar, D.P.

AU - Wright, M.J.

AU - Franke, B.

AU - Martin, N.G.

AU - Thompson, P.M.

AU - Hottenga, J.J.

AU - Boomsma, D.I.

AU - Nalls, M.A.

AU - Uitterlinden, A.G.

AU - Au, R.

AU - Elbaz, A.

AU - Beare, R.J.

AU - van Swieten, J.C.

AU - Lopez, O.L.

AU - Harris, T.B.

AU - Chouraki, V.

AU - Breteler, M.M.B.

AU - de Jager, P.L.

AU - Becker, J.T.

AU - Vernooij, M.W.

AU - Knopman, D.

AU - Fazekas, F.

AU - Wolf, P.A.

AU - van der Lugt, A.

AU - Gudnason, V.

AU - Longstreth, Jr. W.T.

AU - Brown, M.A.

AU - Bennett, D.A.

AU - van Duijn, C.M.

AU - Mosley, T.H.

AU - Schmidt, R.

AU - Tzourio, C.

AU - Launer, L.J.

AU - Arfan Ikram, M.

AU - Seshadri, S.

PY - 2012

Y1 - 2012

N2 - Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10

AB - Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10

U2 - 10.1038/ng.2237

DO - 10.1038/ng.2237

M3 - Article

SN - 1061-4036

VL - 44

SP - 545

EP - 551

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Common variants at 12q14 and 12q24 are associated with hippocampal volume

Abstract

UN SDGs

Cohort Studies

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