Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram; M. Fornage; A.V. Smith; S. Seshadri; R. Schmidt; S. Debette; H.A. Vrooman; S. Sigurdsson; S. Ropele; H.R. Taal; D.O. Mook-Kanamori; L.H. Coker; Jr. W.T. Longstreth; W.J. Niessen; A.L. DeStefano; A. Beiser; A.P. Zijdenbos; M. Struchalin; C.R. Jack; F. Rivadeneira; A.G. Uitterlinden; D.S. Knopman; A.-L. Hartikainen; C.E. Pennell; E. Thiering; E.A.P. Steegers; H. Hakonarson; J. Heinrich; L.J. Palmer; M.-R. Jarvelin; M.I. McCarthy; S.F.A. Grant; B. St Pourcain; N.J. Timpson; G.D. Smith; U. Sovio; C.E.M. van Beijsterveldt; M.M. Groen-Blokhuis; J.J. Hottenga; C.M. Middeldorp; M.G. Nivard; G. Willemsen; D.I. Boomsma; M.A. Nalls; R. Au; A. Hofman; H. Gudnason; A. van der Lugt; T.B. Harris; W.M. Meeks; M.W. Vernooij; M.A. van Buchem; D. Catellier; V.W.V. Jaddoe; V. Gudnason; B.G. Windham; P.A. Wolf; C.M. van Duijn; T.H. Mosley; H. Schmidt; L.J. Launer; M.M.B. Breteler; C.S. DeCarli

doi:10.1038/ng.2245

Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram, M. Fornage, A.V. Smith, S. Seshadri, R. Schmidt, S. Debette, H.A. Vrooman, S. Sigurdsson, S. Ropele, H.R. Taal, D.O. Mook-Kanamori, L.H. Coker, Jr. W.T. Longstreth, W.J. Niessen, A.L. DeStefano, A. Beiser, A.P. Zijdenbos, M. Struchalin, C.R. Jack, F. RivadeneiraA.G. Uitterlinden, D.S. Knopman, A.-L. Hartikainen, C.E. Pennell, E. Thiering, E.A.P. Steegers, H. Hakonarson, J. Heinrich, L.J. Palmer, M.-R. Jarvelin, M.I. McCarthy, S.F.A. Grant, B. St Pourcain, N.J. Timpson, G.D. Smith, U. Sovio, C.E.M. van Beijsterveldt, M.M. Groen-Blokhuis, J.J. Hottenga, C.M. Middeldorp, M.G. Nivard, G. Willemsen, D.I. Boomsma, M.A. Nalls, R. Au, A. Hofman, H. Gudnason, A. van der Lugt, T.B. Harris, W.M. Meeks, M.W. Vernooij, M.A. van Buchem, D. Catellier, V.W.V. Jaddoe, V. Gudnason, B.G. Windham, P.A. Wolf, C.M. van Duijn, T.H. Mosley, H. Schmidt, L.J. Launer, M.M.B. Breteler, C.S. DeCarli

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10

Original language	English
Pages (from-to)	539-544
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2245
Publication status	Published - 2012

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Arfan Ikram, M., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, J. W. T., Niessen, W. J., DeStefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., ... DeCarli, C. S. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44(5), 539-544. https://doi.org/10.1038/ng.2245

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title = "Common variants at 6q22 and 17q21 are associated with intracranial volume",

abstract = "During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10",

author = "{Arfan Ikram}, M. and M. Fornage and A.V. Smith and S. Seshadri and R. Schmidt and S. Debette and H.A. Vrooman and S. Sigurdsson and S. Ropele and H.R. Taal and D.O. Mook-Kanamori and L.H. Coker and Longstreth, {Jr. W.T.} and W.J. Niessen and A.L. DeStefano and A. Beiser and A.P. Zijdenbos and M. Struchalin and C.R. Jack and F. Rivadeneira and A.G. Uitterlinden and D.S. Knopman and A.-L. Hartikainen and C.E. Pennell and E. Thiering and E.A.P. Steegers and H. Hakonarson and J. Heinrich and L.J. Palmer and M.-R. Jarvelin and M.I. McCarthy and S.F.A. Grant and {St Pourcain}, B. and N.J. Timpson and G.D. Smith and U. Sovio and {van Beijsterveldt}, C.E.M. and M.M. Groen-Blokhuis and J.J. Hottenga and C.M. Middeldorp and M.G. Nivard and G. Willemsen and D.I. Boomsma and M.A. Nalls and R. Au and A. Hofman and H. Gudnason and {van der Lugt}, A. and T.B. Harris and W.M. Meeks and M.W. Vernooij and {van Buchem}, M.A. and D. Catellier and V.W.V. Jaddoe and V. Gudnason and B.G. Windham and P.A. Wolf and {van Duijn}, C.M. and T.H. Mosley and H. Schmidt and L.J. Launer and M.M.B. Breteler and C.S. DeCarli",

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doi = "10.1038/ng.2245",

language = "English",

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journal = "Nature Genetics",

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publisher = "Nature Publishing Group",

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Arfan Ikram, M, Fornage, M, Smith, AV, Seshadri, S, Schmidt, R, Debette, S, Vrooman, HA, Sigurdsson, S, Ropele, S, Taal, HR, Mook-Kanamori, DO, Coker, LH, Longstreth, JWT, Niessen, WJ, DeStefano, AL, Beiser, A, Zijdenbos, AP, Struchalin, M, Jack, CR, Rivadeneira, F, Uitterlinden, AG, Knopman, DS, Hartikainen, A-L, Pennell, CE, Thiering, E, Steegers, EAP, Hakonarson, H, Heinrich, J, Palmer, LJ, Jarvelin, M-R, McCarthy, MI, Grant, SFA, St Pourcain, B, Timpson, NJ, Smith, GD, Sovio, U, van Beijsterveldt, CEM, Groen-Blokhuis, MM, Hottenga, JJ, Middeldorp, CM, Nivard, MG, Willemsen, G, Boomsma, DI, Nalls, MA, Au, R, Hofman, A, Gudnason, H, van der Lugt, A, Harris, TB, Meeks, WM, Vernooij, MW, van Buchem, MA, Catellier, D, Jaddoe, VWV, Gudnason, V, Windham, BG, Wolf, PA, van Duijn, CM, Mosley, TH, Schmidt, H, Launer, LJ, Breteler, MMB & DeCarli, CS 2012, 'Common variants at 6q22 and 17q21 are associated with intracranial volume', Nature Genetics, vol. 44, no. 5, pp. 539-544. https://doi.org/10.1038/ng.2245

TY - JOUR

T1 - Common variants at 6q22 and 17q21 are associated with intracranial volume

AU - Arfan Ikram, M.

AU - Fornage, M.

AU - Smith, A.V.

AU - Seshadri, S.

AU - Schmidt, R.

AU - Debette, S.

AU - Vrooman, H.A.

AU - Sigurdsson, S.

AU - Ropele, S.

AU - Taal, H.R.

AU - Mook-Kanamori, D.O.

AU - Coker, L.H.

AU - Longstreth, Jr. W.T.

AU - Niessen, W.J.

AU - DeStefano, A.L.

AU - Beiser, A.

AU - Zijdenbos, A.P.

AU - Struchalin, M.

AU - Jack, C.R.

AU - Rivadeneira, F.

AU - Uitterlinden, A.G.

AU - Knopman, D.S.

AU - Hartikainen, A.-L.

AU - Pennell, C.E.

AU - Thiering, E.

AU - Steegers, E.A.P.

AU - Hakonarson, H.

AU - Heinrich, J.

AU - Palmer, L.J.

AU - Jarvelin, M.-R.

AU - McCarthy, M.I.

AU - Grant, S.F.A.

AU - St Pourcain, B.

AU - Timpson, N.J.

AU - Smith, G.D.

AU - Sovio, U.

AU - van Beijsterveldt, C.E.M.

AU - Groen-Blokhuis, M.M.

AU - Hottenga, J.J.

AU - Middeldorp, C.M.

AU - Nivard, M.G.

AU - Willemsen, G.

AU - Boomsma, D.I.

AU - Nalls, M.A.

AU - Au, R.

AU - Hofman, A.

AU - Gudnason, H.

AU - van der Lugt, A.

AU - Harris, T.B.

AU - Meeks, W.M.

AU - Vernooij, M.W.

AU - van Buchem, M.A.

AU - Catellier, D.

AU - Jaddoe, V.W.V.

AU - Gudnason, V.

AU - Windham, B.G.

AU - Wolf, P.A.

AU - van Duijn, C.M.

AU - Mosley, T.H.

AU - Schmidt, H.

AU - Launer, L.J.

AU - Breteler, M.M.B.

AU - DeCarli, C.S.

PY - 2012

Y1 - 2012

N2 - During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10

AB - During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10

U2 - 10.1038/ng.2245

DO - 10.1038/ng.2245

M3 - Article

SN - 1061-4036

VL - 44

SP - 539

EP - 544

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Common variants at 6q22 and 17q21 are associated with intracranial volume

Abstract

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