Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram, M. Fornage, A.V. Smith, S. Seshadri, R. Schmidt, S. Debette, H.A. Vrooman, S. Sigurdsson, S. Ropele, H.R. Taal, D.O. Mook-Kanamori, L.H. Coker, Jr. W.T. Longstreth, W.J. Niessen, A.L. DeStefano, A. Beiser, A.P. Zijdenbos, M. Struchalin, C.R. Jack, F. RivadeneiraA.G. Uitterlinden, D.S. Knopman, A.-L. Hartikainen, C.E. Pennell, E. Thiering, E.A.P. Steegers, H. Hakonarson, J. Heinrich, L.J. Palmer, M.-R. Jarvelin, M.I. McCarthy, S.F.A. Grant, B. St Pourcain, N.J. Timpson, G.D. Smith, U. Sovio, C.E.M. van Beijsterveldt, M.M. Groen-Blokhuis, J.J. Hottenga, C.M. Middeldorp, M.G. Nivard, G. Willemsen, D.I. Boomsma, M.A. Nalls, R. Au, A. Hofman, H. Gudnason, A. van der Lugt, T.B. Harris, W.M. Meeks, M.W. Vernooij, M.A. van Buchem, D. Catellier, V.W.V. Jaddoe, V. Gudnason, B.G. Windham, P.A. Wolf, C.M. van Duijn, T.H. Mosley, H. Schmidt, L.J. Launer, M.M.B. Breteler, C.S. DeCarli

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10
Original languageEnglish
Pages (from-to)539-544
JournalNature Genetics
Volume44
Issue number5
DOIs
Publication statusPublished - 2012

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Arfan Ikram, M., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., ... DeCarli, C. S. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44(5), 539-544. https://doi.org/10.1038/ng.2245