Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

B. Benyamin; M.A. Ferreira; G. Willemsen; S. Gordon; R.P.S. Middelberg; B.P. McEvoy; J.J. Hottenga; A.K. Henders; MJ Campbell; L. Wallace; I.H. Frazer; A.C. Heath; E.J.C. de Geus; DR Nyholt; P.M. Visscher; B.W.J.H. Penninx; D.I. Boomsma; N.G. Martin; GW Montgomery; J.B. Whitfield

doi:10.1038/ng.456

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

B. Benyamin, M.A. Ferreira, G. Willemsen, S. Gordon, R.P.S. Middelberg, B.P. McEvoy, J.J. Hottenga, A.K. Henders, MJ Campbell, L. Wallace, I.H. Frazer, A.C. Heath, E.J.C. de Geus, DR Nyholt, P.M. Visscher, B.W.J.H. Penninx, D.I. Boomsma, N.G. Martin, GW Montgomery, J.B. Whitfield

Biological Psychology

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Abstract

We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. © 2009 Nature America, Inc. All rights reserved.

Original language	English
Pages (from-to)	1173-1175
Journal	Nature Genetics
Volume	41
Issue number	11
DOIs	https://doi.org/10.1038/ng.456
Publication status	Published - 2009

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Benyamin, B., Ferreira, M. A., Willemsen, G., Gordon, S., Middelberg, R. P. S., McEvoy, B. P., Hottenga, J. J., Henders, A. K., Campbell, MJ., Wallace, L., Frazer, I. H., Heath, A. C., de Geus, E. J. C., Nyholt, DR., Visscher, P. M., Penninx, B. W. J. H., Boomsma, D. I., Martin, N. G., Montgomery, GW., & Whitfield, J. B. (2009). Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nature Genetics, 41(11), 1173-1175. https://doi.org/10.1038/ng.456

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title = "Common variants in TMPRSS6 are associated with iron status and erythrocyte volume",

abstract = "We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. {\textcopyright} 2009 Nature America, Inc. All rights reserved.",

author = "B. Benyamin and M.A. Ferreira and G. Willemsen and S. Gordon and R.P.S. Middelberg and B.P. McEvoy and J.J. Hottenga and A.K. Henders and MJ Campbell and L. Wallace and I.H. Frazer and A.C. Heath and \{de Geus\}, E.J.C. and DR Nyholt and P.M. Visscher and B.W.J.H. Penninx and D.I. Boomsma and N.G. Martin and GW Montgomery and J.B. Whitfield",

year = "2009",

doi = "10.1038/ng.456",

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volume = "41",

pages = "1173--1175",

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Benyamin, B, Ferreira, MA, Willemsen, G, Gordon, S, Middelberg, RPS, McEvoy, BP, Hottenga, JJ, Henders, AK, Campbell, MJ, Wallace, L, Frazer, IH, Heath, AC, de Geus, EJC, Nyholt, DR, Visscher, PM, Penninx, BWJH, Boomsma, DI, Martin, NG, Montgomery, GW & Whitfield, JB 2009, 'Common variants in TMPRSS6 are associated with iron status and erythrocyte volume', Nature Genetics, vol. 41, no. 11, pp. 1173-1175. https://doi.org/10.1038/ng.456

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T1 - Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

AU - Benyamin, B.

AU - Ferreira, M.A.

AU - Willemsen, G.

AU - Gordon, S.

AU - Middelberg, R.P.S.

AU - McEvoy, B.P.

AU - Hottenga, J.J.

AU - Henders, A.K.

AU - Campbell, MJ

AU - Wallace, L.

AU - Frazer, I.H.

AU - Heath, A.C.

AU - de Geus, E.J.C.

AU - Nyholt, DR

AU - Visscher, P.M.

AU - Penninx, B.W.J.H.

AU - Boomsma, D.I.

AU - Martin, N.G.

AU - Montgomery, GW

AU - Whitfield, J.B.

PY - 2009

Y1 - 2009

N2 - We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. © 2009 Nature America, Inc. All rights reserved.

AB - We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 × 10 20), transferrin saturation (combined P = 2.2 × 10 23) and erythrocyte mean cell volume (MCV, combined P = 1.1 × 10 10). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 × 10 7). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis. © 2009 Nature America, Inc. All rights reserved.

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SP - 1173

EP - 1175

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

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