Comparative effectiveness of conservative and pharmacological interventions for chronic non-specific neck pain: Protocol of a systematic review and network meta-analysis

Paolo Pillastrini; Greta Castellini; Alessandro Chiarotto; Francesco Fasciani; Francesco Marzioni; Carla Vanti; Lucia Bertozzi; Silvia Gianola

doi:10.1097/MD.0000000000016762

Comparative effectiveness of conservative and pharmacological interventions for chronic non-specific neck pain: Protocol of a systematic review and network meta-analysis

Paolo Pillastrini, Greta Castellini^*, Alessandro Chiarotto, Francesco Fasciani, Francesco Marzioni, Carla Vanti, Lucia Bertozzi, Silvia Gianola

^*Corresponding author for this work

Health Economics and Health Technology Assessment

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background:Neck Pain (NP) has been ranked as one of the top chronic pain conditions in terms of prevalence and years lived with disability in the latest Global Burden of Disease. NP has remarkable socio-economic consequences however, research efforts are limited. Discrepancies among guidelines recommendations on management of chronic neck pain exist. The purpose of this study protocol is to provide the methods for a review with network meta-analysis to identify the most effective interventions for chronic neck pain.Methods:The following databases will be searched from their inception to February 2019: Cochrane Controlled Trials Register (CENTRAL), PubMed, CINAHL, Scopus, ISI Web of Science and PEDro.Randomized controlled trials (RCTs) on pharmacological and not pharmacological interventions will be included and their risk of bias will be evaluated using the Cochrane Risk of bias tool. Primary outcomes will be reduction in pain and disability. A network meta-analysis will be carried out and pairwise meta-analysis will be conducted using Stata 15 software. Grading of recommendations assessment, development, and evaluation (GRADE) will be applied to assess quality of the body of the evidence.Results:The results of this review will be submitted to a peer-review journal for publication.Conclusion:This network meta-analysis will provide a comprehensive review on the most effective treatments for the management of chronic neck pain providing key evidence-based information to patients, clinicians and other relevant stakeholders. Registration: PROSPERO (registration number CRD42019124501).

Original language	English
Article number	e16762
Journal	Medicine (United States)
Volume	98
Issue number	33
DOIs	https://doi.org/10.1097/MD.0000000000016762
Publication status	Published - 1 Aug 2019

Funding

No ethical approval is needed since all the clinical studies included were approved by ethical committees and institutional review boards besides, patients signed a written informed consent. The work was supported by the Italian Ministry of Health “Efficacia degli interventi riabilitativi nel back pain: una network meta-analisi” (L3026). The funding sources had no controlling role in the study design, data collection, analysis, interpretation, or report writing. The authors report no conflicts of interest. Supplemental Digital Content is available for this article. aDepartment of Biomedical and Neuromotor Sciences (DIBINEM) – University of Bologna, Italy, bIRCCS Istituto Ortopedico Galeazzi, Unit of Clinical Epidemiology, Milan, cDepartment of General Practice – Erasmus MC - University Medical Center Rotterdam; Department of Health Sciences – Amsterdam Movement Sciences Research Institute – VU University Amsterdam, the Netherlands. ∗Correspondence: Greta Castellini, IRCCS Istituto Ortopedico Galeazzi, via R.Galeazzi 4, 20161, Milan, Lombardia, Italy (e-mail: [email protected]).

Funders	Funder number
Italian Ministry of Health
Ministero della Salute	L3026

Keywords

neck pain
network meta-analysis
rehabilitation
review
therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Pillastrini, P., Castellini, G., Chiarotto, A., Fasciani, F., Marzioni, F., Vanti, C., Bertozzi, L., & Gianola, S. (2019). Comparative effectiveness of conservative and pharmacological interventions for chronic non-specific neck pain: Protocol of a systematic review and network meta-analysis. Medicine (United States), 98(33), Article e16762. https://doi.org/10.1097/MD.0000000000016762

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abstract = "Background:Neck Pain (NP) has been ranked as one of the top chronic pain conditions in terms of prevalence and years lived with disability in the latest Global Burden of Disease. NP has remarkable socio-economic consequences however, research efforts are limited. Discrepancies among guidelines recommendations on management of chronic neck pain exist. The purpose of this study protocol is to provide the methods for a review with network meta-analysis to identify the most effective interventions for chronic neck pain.Methods:The following databases will be searched from their inception to February 2019: Cochrane Controlled Trials Register (CENTRAL), PubMed, CINAHL, Scopus, ISI Web of Science and PEDro.Randomized controlled trials (RCTs) on pharmacological and not pharmacological interventions will be included and their risk of bias will be evaluated using the Cochrane Risk of bias tool. Primary outcomes will be reduction in pain and disability. A network meta-analysis will be carried out and pairwise meta-analysis will be conducted using Stata 15 software. Grading of recommendations assessment, development, and evaluation (GRADE) will be applied to assess quality of the body of the evidence.Results:The results of this review will be submitted to a peer-review journal for publication.Conclusion:This network meta-analysis will provide a comprehensive review on the most effective treatments for the management of chronic neck pain providing key evidence-based information to patients, clinicians and other relevant stakeholders. Registration: PROSPERO (registration number CRD42019124501).",

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Pillastrini, P, Castellini, G, Chiarotto, A, Fasciani, F, Marzioni, F, Vanti, C, Bertozzi, L & Gianola, S 2019, 'Comparative effectiveness of conservative and pharmacological interventions for chronic non-specific neck pain: Protocol of a systematic review and network meta-analysis', Medicine (United States), vol. 98, no. 33, e16762. https://doi.org/10.1097/MD.0000000000016762

Comparative effectiveness of conservative and pharmacological interventions for chronic non-specific neck pain: Protocol of a systematic review and network meta-analysis. / Pillastrini, Paolo; Castellini, Greta; Chiarotto, Alessandro et al.
In: Medicine (United States), Vol. 98, No. 33, e16762, 01.08.2019.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Comparative effectiveness of conservative and pharmacological interventions for chronic non-specific neck pain

T2 - Protocol of a systematic review and network meta-analysis

AU - Pillastrini, Paolo

AU - Castellini, Greta

AU - Chiarotto, Alessandro

AU - Fasciani, Francesco

AU - Marzioni, Francesco

AU - Vanti, Carla

AU - Bertozzi, Lucia

AU - Gianola, Silvia

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Background:Neck Pain (NP) has been ranked as one of the top chronic pain conditions in terms of prevalence and years lived with disability in the latest Global Burden of Disease. NP has remarkable socio-economic consequences however, research efforts are limited. Discrepancies among guidelines recommendations on management of chronic neck pain exist. The purpose of this study protocol is to provide the methods for a review with network meta-analysis to identify the most effective interventions for chronic neck pain.Methods:The following databases will be searched from their inception to February 2019: Cochrane Controlled Trials Register (CENTRAL), PubMed, CINAHL, Scopus, ISI Web of Science and PEDro.Randomized controlled trials (RCTs) on pharmacological and not pharmacological interventions will be included and their risk of bias will be evaluated using the Cochrane Risk of bias tool. Primary outcomes will be reduction in pain and disability. A network meta-analysis will be carried out and pairwise meta-analysis will be conducted using Stata 15 software. Grading of recommendations assessment, development, and evaluation (GRADE) will be applied to assess quality of the body of the evidence.Results:The results of this review will be submitted to a peer-review journal for publication.Conclusion:This network meta-analysis will provide a comprehensive review on the most effective treatments for the management of chronic neck pain providing key evidence-based information to patients, clinicians and other relevant stakeholders. Registration: PROSPERO (registration number CRD42019124501).

AB - Background:Neck Pain (NP) has been ranked as one of the top chronic pain conditions in terms of prevalence and years lived with disability in the latest Global Burden of Disease. NP has remarkable socio-economic consequences however, research efforts are limited. Discrepancies among guidelines recommendations on management of chronic neck pain exist. The purpose of this study protocol is to provide the methods for a review with network meta-analysis to identify the most effective interventions for chronic neck pain.Methods:The following databases will be searched from their inception to February 2019: Cochrane Controlled Trials Register (CENTRAL), PubMed, CINAHL, Scopus, ISI Web of Science and PEDro.Randomized controlled trials (RCTs) on pharmacological and not pharmacological interventions will be included and their risk of bias will be evaluated using the Cochrane Risk of bias tool. Primary outcomes will be reduction in pain and disability. A network meta-analysis will be carried out and pairwise meta-analysis will be conducted using Stata 15 software. Grading of recommendations assessment, development, and evaluation (GRADE) will be applied to assess quality of the body of the evidence.Results:The results of this review will be submitted to a peer-review journal for publication.Conclusion:This network meta-analysis will provide a comprehensive review on the most effective treatments for the management of chronic neck pain providing key evidence-based information to patients, clinicians and other relevant stakeholders. Registration: PROSPERO (registration number CRD42019124501).

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KW - network meta-analysis

KW - rehabilitation

KW - review

KW - therapeutics

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U2 - 10.1097/MD.0000000000016762

DO - 10.1097/MD.0000000000016762

M3 - Article

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AN - SCOPUS:85070774995

SN - 0025-7974

VL - 98

JO - Medicine (United States)

JF - Medicine (United States)

IS - 33

M1 - e16762

ER -

Comparative effectiveness of conservative and pharmacological interventions for chronic non-specific neck pain: Protocol of a systematic review and network meta-analysis

Abstract

Funding

Keywords

UN SDGs

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