Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time: Cohort differences in the Longitudinal Aging Study Amsterdam

E.M. van Zutphen; A.A.L. Kok; D. Rhebergen; N.M. van Schoor; M. Huisman; A.T.F. Beekman

doi:10.1016/j.jpsychores.2022.111015

Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time: Cohort differences in the Longitudinal Aging Study Amsterdam

E.M. van Zutphen
, A.A.L. Kok
, D. Rhebergen
, N.M. van Schoor
, M. Huisman
, A.T.F. Beekman

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

© 2022 The AuthorsObjective: Previous studies suggest that prevention of cardiovascular disease (CVD) is more difficult in depressed persons. Although the prevalence and incidence of CVD decreased over the past decades, it is uncertain whether this is also true for depressed persons. This study examined whether changes in the prevalence and incidence of CVD differ between depressed and non-depressed older persons. Methods: Longitudinal data from three community-based representative birth cohorts aged 55–65 years of the Longitudinal Aging Study Amsterdam were used; N = 1070 born in 1926–1937, N = 995 born in 1938–1947, N = 1019 born in 1948–1957. The outcome included fatal and non-fatal CVD. Depression was defined as ≥16 points on the Center for Epidemiological Studies Depression Scale or a general practitioner's diagnosis of depression. Data were analysed with for age and sex adjusted logistic regression and cox regression models. Results: Comparing cohort 2 and 3 with cohort 1 in the complete sample, the prevalence of CVD decreased by 2% (OR = 0.98, 95%CI = 0.76–1.26) and 32% (OR = 0.68, 95%CI = 0.52–0.89), respectively, and the three-year incidence of CVD decreased by 6% (OR = 0.94, 95%CI = 0.63–1.41) and 26% (OR = 0.74, 95%CI = 0.48–1.15), respectively. The 13-year incidence of CVD decreased by 19% (HR = 0.81, 95%CI = 0.67–0.99) in cohort 2 compared to cohort 1. These decreases did not differ statistically significantly between depressed and non-depressed respondents (p-values of interaction terms: 0.35–0.98). Conclusion: Substantial decreases in the prevalence and incidence of CVD were observed in depressed and non-depressed older persons. Although this is encouraging, cardiovascular risk remained higher in depressed persons over time, warranting tailored prevention programs for depressed older persons.

Original language	English
Article number	111015
Journal	Journal of Psychosomatic Research
Volume	162
DOIs	https://doi.org/10.1016/j.jpsychores.2022.111015
Publication status	Published - 1 Nov 2022

Funding

The Longitudinal Aging Study Amsterdam is supported by a grant from the Netherlands Ministry of Health, Welfare and Sport, Directorate of Long-Term Care. The data collection in 2012–2013 was financially supported by the Netherlands Organization for Scientific Research (NWO) in the framework of the project “New Cohorts of young old in the 21st century” (file number 480-10-014). The funders had no role in study design, data collection, analysis and interpretation, decision to publish, or preparation of the manuscript. The authors of this paper did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors and have no competing interests to report. The Longitudinal Aging Study Amsterdam is supported by a grant from the Netherlands Ministry of Health, Welfare and Sport , Directorate of Long-Term Care. The data collection in 2012–2013 was financially supported by the Netherlands Organization for Scientific Research (NWO) in the framework of the project “New Cohorts of young old in the 21st century” (file number 480-10-014 ). The funders had no role in study design, data collection, analysis and interpretation, decision to publish, or preparation of the manuscript. The authors of this paper did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors and have no competing interests to report.

Funders	Funder number
Netherlands Ministry of Health, Welfare and Sport , Directorate of Long-Term Care
Netherlands Ministry of Health, Welfare and Sport, Directorate of Long-Term Care
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	480-10-014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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van Zutphen, E. M., Kok, A. A. L., Rhebergen, D., van Schoor, N. M., Huisman, M., & Beekman, A. T. F. (2022). Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time: Cohort differences in the Longitudinal Aging Study Amsterdam. Journal of Psychosomatic Research, 162, Article 111015. https://doi.org/10.1016/j.jpsychores.2022.111015

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title = "Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time: Cohort differences in the Longitudinal Aging Study Amsterdam",

abstract = "{\textcopyright} 2022 The AuthorsObjective: Previous studies suggest that prevention of cardiovascular disease (CVD) is more difficult in depressed persons. Although the prevalence and incidence of CVD decreased over the past decades, it is uncertain whether this is also true for depressed persons. This study examined whether changes in the prevalence and incidence of CVD differ between depressed and non-depressed older persons. Methods: Longitudinal data from three community-based representative birth cohorts aged 55–65 years of the Longitudinal Aging Study Amsterdam were used; N = 1070 born in 1926–1937, N = 995 born in 1938–1947, N = 1019 born in 1948–1957. The outcome included fatal and non-fatal CVD. Depression was defined as ≥16 points on the Center for Epidemiological Studies Depression Scale or a general practitioner's diagnosis of depression. Data were analysed with for age and sex adjusted logistic regression and cox regression models. Results: Comparing cohort 2 and 3 with cohort 1 in the complete sample, the prevalence of CVD decreased by 2\% (OR = 0.98, 95\%CI = 0.76–1.26) and 32\% (OR = 0.68, 95\%CI = 0.52–0.89), respectively, and the three-year incidence of CVD decreased by 6\% (OR = 0.94, 95\%CI = 0.63–1.41) and 26\% (OR = 0.74, 95\%CI = 0.48–1.15), respectively. The 13-year incidence of CVD decreased by 19\% (HR = 0.81, 95\%CI = 0.67–0.99) in cohort 2 compared to cohort 1. These decreases did not differ statistically significantly between depressed and non-depressed respondents (p-values of interaction terms: 0.35–0.98). Conclusion: Substantial decreases in the prevalence and incidence of CVD were observed in depressed and non-depressed older persons. Although this is encouraging, cardiovascular risk remained higher in depressed persons over time, warranting tailored prevention programs for depressed older persons.",

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van Zutphen, EM, Kok, AAL, Rhebergen, D, van Schoor, NM, Huisman, M & Beekman, ATF 2022, 'Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time: Cohort differences in the Longitudinal Aging Study Amsterdam', Journal of Psychosomatic Research, vol. 162, 111015. https://doi.org/10.1016/j.jpsychores.2022.111015

Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time: Cohort differences in the Longitudinal Aging Study Amsterdam. / van Zutphen, E.M.; Kok, A.A.L.; Rhebergen, D. et al.
In: Journal of Psychosomatic Research, Vol. 162, 111015, 01.11.2022.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time

T2 - Cohort differences in the Longitudinal Aging Study Amsterdam

AU - van Zutphen, E.M.

AU - Kok, A.A.L.

AU - Rhebergen, D.

AU - van Schoor, N.M.

AU - Huisman, M.

AU - Beekman, A.T.F.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - © 2022 The AuthorsObjective: Previous studies suggest that prevention of cardiovascular disease (CVD) is more difficult in depressed persons. Although the prevalence and incidence of CVD decreased over the past decades, it is uncertain whether this is also true for depressed persons. This study examined whether changes in the prevalence and incidence of CVD differ between depressed and non-depressed older persons. Methods: Longitudinal data from three community-based representative birth cohorts aged 55–65 years of the Longitudinal Aging Study Amsterdam were used; N = 1070 born in 1926–1937, N = 995 born in 1938–1947, N = 1019 born in 1948–1957. The outcome included fatal and non-fatal CVD. Depression was defined as ≥16 points on the Center for Epidemiological Studies Depression Scale or a general practitioner's diagnosis of depression. Data were analysed with for age and sex adjusted logistic regression and cox regression models. Results: Comparing cohort 2 and 3 with cohort 1 in the complete sample, the prevalence of CVD decreased by 2% (OR = 0.98, 95%CI = 0.76–1.26) and 32% (OR = 0.68, 95%CI = 0.52–0.89), respectively, and the three-year incidence of CVD decreased by 6% (OR = 0.94, 95%CI = 0.63–1.41) and 26% (OR = 0.74, 95%CI = 0.48–1.15), respectively. The 13-year incidence of CVD decreased by 19% (HR = 0.81, 95%CI = 0.67–0.99) in cohort 2 compared to cohort 1. These decreases did not differ statistically significantly between depressed and non-depressed respondents (p-values of interaction terms: 0.35–0.98). Conclusion: Substantial decreases in the prevalence and incidence of CVD were observed in depressed and non-depressed older persons. Although this is encouraging, cardiovascular risk remained higher in depressed persons over time, warranting tailored prevention programs for depressed older persons.

AB - © 2022 The AuthorsObjective: Previous studies suggest that prevention of cardiovascular disease (CVD) is more difficult in depressed persons. Although the prevalence and incidence of CVD decreased over the past decades, it is uncertain whether this is also true for depressed persons. This study examined whether changes in the prevalence and incidence of CVD differ between depressed and non-depressed older persons. Methods: Longitudinal data from three community-based representative birth cohorts aged 55–65 years of the Longitudinal Aging Study Amsterdam were used; N = 1070 born in 1926–1937, N = 995 born in 1938–1947, N = 1019 born in 1948–1957. The outcome included fatal and non-fatal CVD. Depression was defined as ≥16 points on the Center for Epidemiological Studies Depression Scale or a general practitioner's diagnosis of depression. Data were analysed with for age and sex adjusted logistic regression and cox regression models. Results: Comparing cohort 2 and 3 with cohort 1 in the complete sample, the prevalence of CVD decreased by 2% (OR = 0.98, 95%CI = 0.76–1.26) and 32% (OR = 0.68, 95%CI = 0.52–0.89), respectively, and the three-year incidence of CVD decreased by 6% (OR = 0.94, 95%CI = 0.63–1.41) and 26% (OR = 0.74, 95%CI = 0.48–1.15), respectively. The 13-year incidence of CVD decreased by 19% (HR = 0.81, 95%CI = 0.67–0.99) in cohort 2 compared to cohort 1. These decreases did not differ statistically significantly between depressed and non-depressed respondents (p-values of interaction terms: 0.35–0.98). Conclusion: Substantial decreases in the prevalence and incidence of CVD were observed in depressed and non-depressed older persons. Although this is encouraging, cardiovascular risk remained higher in depressed persons over time, warranting tailored prevention programs for depressed older persons.

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U2 - 10.1016/j.jpsychores.2022.111015

DO - 10.1016/j.jpsychores.2022.111015

M3 - Article

SN - 0022-3999

VL - 162

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

M1 - 111015

ER -

Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time: Cohort differences in the Longitudinal Aging Study Amsterdam

Abstract

Funding

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