Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix

T. Husøy; M. A. Martínez; R. P. Sharma; V. Kumar; M. Andreassen; A. K. Sakhi; C. Thomsen; H. Dirven

doi:10.1016/j.fct.2020.111510

Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix

T. Husøy^*, M. A. Martínez, R. P. Sharma, V. Kumar, M. Andreassen, A. K. Sakhi, C. Thomsen, H. Dirven

^*Corresponding author for this work

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Phthalates are widely used as plasticisers in flexible plastics and containers for food and personal care products (PCPs) and contaminates foods and PCPs. A human biomonitoring (BM) study was performed to study exposure of chemicals from foods and PCPs. For two 24-h periods, adult volunteers (n = 144) in Norway kept diaries on food eaten and usage of PCPs, and collected 24-h urine. Aggregated exposure to di(2-ethylhexyl) phthalate (DEHP) from dietary and PCPs was estimated by Monte-Carlo simulation using Oracle Crystal Ball

Original language	English
Article number	111510
Pages (from-to)	1-11
Number of pages	11
Journal	Food and Chemical Toxicology
Volume	143
Early online date	30 Jun 2020
DOIs	https://doi.org/10.1016/j.fct.2020.111510
Publication status	Published - Sept 2020

Funding

This study is part of the EuroMix project (No. 633172 ) funded in the framework of Horizon 2020 ( H2020-SFS-2014-2 ). V. Kumar has been funded from Health Department of Catalonia Government through "Pla Estratègic de Recerca i Innovació en salut" (PERIS, 2016–2020). Part of M.A. Martinez work was funded by Ministeri de Ciència, Innovació i Universitats (MICIU) i l'agència Estatal d'investigació (AEI) through the PCIN-2017-012 -"Interrelación del microbioma intestinal, dieta y salud" project. This study is part of the EuroMix project (No. 633172) funded in the framework of Horizon 2020 (H2020-SFS-2014-2). V. Kumar has been funded from Health Department of Catalonia Government through ?Pla Estrat?gic de Recerca i Innovaci? en salut? (PERIS, 2016?2020). Part of M.A. Martinez work was funded by Ministeri de Ci?ncia, Innovaci? i Universitats (MICIU) i l'ag?ncia Estatal d'investigaci? (AEI) through the PCIN-2017-012-"Interrelaci?n del microbioma intestinal, dieta y salud" project.

Funders	Funder number
Health Department of Catalonia Government
MICIU
Ministeri de Ci?ncia
Ministeri de Ciència, Innovació i Universitats
Australian Education International, Australian Government
Horizon 2020	H2020-SFS-2014-2
Agencia Estatal de Investigación	PCIN-2017-012

Keywords

Exposure
Human biomonitoring
PBPK
Phthalates

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Husøy, T., Martínez, M. A., Sharma, R. P., Kumar, V., Andreassen, M., Sakhi, A. K., Thomsen, C., & Dirven, H. (2020). Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix. Food and Chemical Toxicology, 143, 1-11. Article 111510. https://doi.org/10.1016/j.fct.2020.111510

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abstract = "Phthalates are widely used as plasticisers in flexible plastics and containers for food and personal care products (PCPs) and contaminates foods and PCPs. A human biomonitoring (BM) study was performed to study exposure of chemicals from foods and PCPs. For two 24-h periods, adult volunteers (n = 144) in Norway kept diaries on food eaten and usage of PCPs, and collected 24-h urine. Aggregated exposure to di(2-ethylhexyl) phthalate (DEHP) from dietary and PCPs was estimated by Monte-Carlo simulation using Oracle Crystal Ball",

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Husøy, T, Martínez, MA, Sharma, RP, Kumar, V, Andreassen, M, Sakhi, AK, Thomsen, C & Dirven, H 2020, 'Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix', Food and Chemical Toxicology, vol. 143, 111510, pp. 1-11. https://doi.org/10.1016/j.fct.2020.111510

Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix. / Husøy, T.; Martínez, M. A.; Sharma, R. P. et al.
In: Food and Chemical Toxicology, Vol. 143, 111510, 09.2020, p. 1-11.

Research output: Contribution to Journal › Article › Academic › peer-review

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Husøy T, Martínez MA, Sharma RP, Kumar V, Andreassen M, Sakhi AK et al. Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix. Food and Chemical Toxicology. 2020 Sept;143:1-11. 111510. Epub 2020 Jun 30. doi: 10.1016/j.fct.2020.111510

Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix

Abstract

Funding

Keywords

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