Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition

E.M. Stjernschantz; J. Reinen; W. Meinl; B.J. George; H. Glatt; N.P.E. Vermeulen; C. Oostenbrink

doi:10.1016/j.mce.2009.12.001

Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition

E.M. Stjernschantz, J. Reinen, W. Meinl, B.J. George, H. Glatt, N.P.E. Vermeulen, C. Oostenbrink

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Abstract

It is well established that various endocrine disrupting compounds (EDCs) can inhibit human estrogen sulfotransferase (SULT1E1). In this study, we investigate murine SULT1E1 inhibition in vitro and in silico and compare this to data for the human enzyme. 34 potential EDCs were screened for their ability to inhibit both murine and human SULT1E1 and IC

Original language	English
Pages (from-to)	127-140
Journal	Molecular and Cellular Endocrinology
Volume	137
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2009.12.001
Publication status	Published - 2010

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10.1016/j.mce.2009.12.001

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Stjernschantz, E. M., Reinen, J., Meinl, W., George, B. J., Glatt, H., Vermeulen, N. P. E., & Oostenbrink, C. (2010). Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition. Molecular and Cellular Endocrinology, 137(1-2), 127-140. https://doi.org/10.1016/j.mce.2009.12.001

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title = "Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition",

abstract = "It is well established that various endocrine disrupting compounds (EDCs) can inhibit human estrogen sulfotransferase (SULT1E1). In this study, we investigate murine SULT1E1 inhibition in vitro and in silico and compare this to data for the human enzyme. 34 potential EDCs were screened for their ability to inhibit both murine and human SULT1E1 and IC",

author = "E.M. Stjernschantz and J. Reinen and W. Meinl and B.J. George and H. Glatt and N.P.E. Vermeulen and C. Oostenbrink",

year = "2010",

doi = "10.1016/j.mce.2009.12.001",

language = "English",

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pages = "127--140",

journal = "Molecular and Cellular Endocrinology",

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Stjernschantz, EM, Reinen, J, Meinl, W, George, BJ, Glatt, H, Vermeulen, NPE & Oostenbrink, C 2010, 'Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition', Molecular and Cellular Endocrinology, vol. 137, no. 1-2, pp. 127-140. https://doi.org/10.1016/j.mce.2009.12.001

Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition. / Stjernschantz, E.M.; Reinen, J.; Meinl, W. et al.
In: Molecular and Cellular Endocrinology, Vol. 137, No. 1-2, 2010, p. 127-140.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition

AU - Stjernschantz, E.M.

AU - Reinen, J.

AU - Meinl, W.

AU - George, B.J.

AU - Glatt, H.

AU - Vermeulen, N.P.E.

AU - Oostenbrink, C.

PY - 2010

Y1 - 2010

N2 - It is well established that various endocrine disrupting compounds (EDCs) can inhibit human estrogen sulfotransferase (SULT1E1). In this study, we investigate murine SULT1E1 inhibition in vitro and in silico and compare this to data for the human enzyme. 34 potential EDCs were screened for their ability to inhibit both murine and human SULT1E1 and IC

AB - It is well established that various endocrine disrupting compounds (EDCs) can inhibit human estrogen sulfotransferase (SULT1E1). In this study, we investigate murine SULT1E1 inhibition in vitro and in silico and compare this to data for the human enzyme. 34 potential EDCs were screened for their ability to inhibit both murine and human SULT1E1 and IC

U2 - 10.1016/j.mce.2009.12.001

DO - 10.1016/j.mce.2009.12.001

M3 - Article

SN - 0303-7207

VL - 137

SP - 127

EP - 140

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

IS - 1-2

ER -

Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition

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