Comparison of pain-generated functional outcomes in experimental models of delayed-onset muscle soreness and nerve growth factor injection of the masticatory muscles

Yuanxiu Zhang; Fernando G. Exposto; Anastasios Grigoriadis; Frank Lobbezoo; Michail Koutris; Jinglu Zhang; Lin Wang; Peter Svensson

doi:10.11607/ofph.2623

Comparison of pain-generated functional outcomes in experimental models of delayed-onset muscle soreness and nerve growth factor injection of the masticatory muscles

Yuanxiu Zhang, Fernando G. Exposto, Anastasios Grigoriadis, Frank Lobbezoo, Michail Koutris, Jinglu Zhang^*, Lin Wang, Peter Svensson

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

To compare two pain models of myalgic TMD, delayed-onset muscle soreness (DOMS) and injections of nerve growth factor (NGF), in terms of pain-related and motor function outcomes, as well as activity-related temporal summation. Methods: Fifty age- and gender-matched healthy participants were recruited and randomized into one of three groups: to a repeated eccentric contraction task to cause DOMS (n = 20), to receive NGF injections into the masseter muscle (n = 20), or to a control group (n = 10). Mechanical sensitivity of masticatory muscles, chewing parameters, jaw function limitation, maximum bite force, and activity-related temporal summation were assessed at baseline and at days 1, 2, and 7 following the intervention. Results: Compared to baseline, both model groups showed increased mechanical sensitivity, jaw function limitation, pain on chewing, and decreased chewing efﬁciency, lasting longer in the NGF group than in the DOMS group (P <.05). Furthermore, also compared to baseline, the NGF group showed increased pain on maximum bite and decreased pain-free maximum opening (P <.05). No increases in activity-related temporal summation were shown for any of the model groups when compared to baseline or the control group (P >.05). Conclusion: Both models produced similar pain- related outcomes, with the NGF model having a longer effect. Furthermore, the NGF model showed a more substantial effect on motor function, which was not seen for the DOMS model. Finally, neither of the models were able to provoke activity-related temporal summation of pain. J Oral Facial Pain Headache 2020;34:311–322. doi: 10.11607/ofph.2623

Original language	English
Pages (from-to)	311-322
Number of pages	12
Journal	Journal of oral & facial pain and headache
Volume	34
Issue number	4
DOIs	https://doi.org/10.11607/ofph.2623
Publication status	Published - Oct 2020

Bibliographical note

Funding Information:
This work was funded by the Section of Orofacial Pain and Jaw Function, Department of Dentistry, Aarhus University, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, 2018-87) and the Chinese Government Scholarship Fund from China Scholarship Council (201708320348). The authors thank all staff of the Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University for their selfless help. They would also like to thank Bente Haugsted for help with preparing the NGF injections, Akiko Shimada for providing the chewing gum, and Karina H. Bendixen for her contribution to the study. The authors declare no conflicts of interest. P.S., M.K., F.G.E., Y.Z.: contributed to study design and acquisition of data; F.G.E., Y.Z.: drafted the article. All authors revised the article for important intellectual concent.

Publisher Copyright:
© 2020 by Quintessence Publishing Co Inc.

Keywords

experimental pain
mechanical sensitivity
myalgia
temporal summation
trigeminal motor physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.11607/ofph.2623

Persistent URL (handle)

Persistent link

Cite this

Zhang, Y., Exposto, F. G., Grigoriadis, A., Lobbezoo, F., Koutris, M., Zhang, J., Wang, L., & Svensson, P. (2020). Comparison of pain-generated functional outcomes in experimental models of delayed-onset muscle soreness and nerve growth factor injection of the masticatory muscles. Journal of oral & facial pain and headache, 34(4), 311-322. https://doi.org/10.11607/ofph.2623

@article{8abcdf95f4134be8a6517a4a737f7b1e,

title = "Comparison of pain-generated functional outcomes in experimental models of delayed-onset muscle soreness and nerve growth factor injection of the masticatory muscles",

abstract = "To compare two pain models of myalgic TMD, delayed-onset muscle soreness (DOMS) and injections of nerve growth factor (NGF), in terms of pain-related and motor function outcomes, as well as activity-related temporal summation. Methods: Fifty age- and gender-matched healthy participants were recruited and randomized into one of three groups: to a repeated eccentric contraction task to cause DOMS (n = 20), to receive NGF injections into the masseter muscle (n = 20), or to a control group (n = 10). Mechanical sensitivity of masticatory muscles, chewing parameters, jaw function limitation, maximum bite force, and activity-related temporal summation were assessed at baseline and at days 1, 2, and 7 following the intervention. Results: Compared to baseline, both model groups showed increased mechanical sensitivity, jaw function limitation, pain on chewing, and decreased chewing efﬁciency, lasting longer in the NGF group than in the DOMS group (P <.05). Furthermore, also compared to baseline, the NGF group showed increased pain on maximum bite and decreased pain-free maximum opening (P <.05). No increases in activity-related temporal summation were shown for any of the model groups when compared to baseline or the control group (P >.05). Conclusion: Both models produced similar pain- related outcomes, with the NGF model having a longer effect. Furthermore, the NGF model showed a more substantial effect on motor function, which was not seen for the DOMS model. Finally, neither of the models were able to provoke activity-related temporal summation of pain. J Oral Facial Pain Headache 2020;34:311–322. doi: 10.11607/ofph.2623",

keywords = "experimental pain, mechanical sensitivity, myalgia, temporal summation, trigeminal motor physiology",

author = "Yuanxiu Zhang and Exposto, {Fernando G.} and Anastasios Grigoriadis and Frank Lobbezoo and Michail Koutris and Jinglu Zhang and Lin Wang and Peter Svensson",

note = "Funding Information: This work was funded by the Section of Orofacial Pain and Jaw Function, Department of Dentistry, Aarhus University, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, 2018-87) and the Chinese Government Scholarship Fund from China Scholarship Council (201708320348). The authors thank all staff of the Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University for their selfless help. They would also like to thank Bente Haugsted for help with preparing the NGF injections, Akiko Shimada for providing the chewing gum, and Karina H. Bendixen for her contribution to the study. The authors declare no conflicts of interest. P.S., M.K., F.G.E., Y.Z.: contributed to study design and acquisition of data; F.G.E., Y.Z.: drafted the article. All authors revised the article for important intellectual concent. Publisher Copyright: {\textcopyright} 2020 by Quintessence Publishing Co Inc.",

year = "2020",

month = oct,

doi = "10.11607/ofph.2623",

language = "English",

volume = "34",

pages = "311--322",

journal = "Journal of oral & facial pain and headache",

issn = "2333-0384",

publisher = "Quintessence Publishing Company",

number = "4",

}

Zhang, Y, Exposto, FG, Grigoriadis, A, Lobbezoo, F , Koutris, M, Zhang, J, Wang, L & Svensson, P 2020, 'Comparison of pain-generated functional outcomes in experimental models of delayed-onset muscle soreness and nerve growth factor injection of the masticatory muscles', Journal of oral & facial pain and headache, vol. 34, no. 4, pp. 311-322. https://doi.org/10.11607/ofph.2623

Comparison of pain-generated functional outcomes in experimental models of delayed-onset muscle soreness and nerve growth factor injection of the masticatory muscles. / Zhang, Yuanxiu; Exposto, Fernando G.; Grigoriadis, Anastasios et al.
In: Journal of oral & facial pain and headache, Vol. 34, No. 4, 10.2020, p. 311-322.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Comparison of pain-generated functional outcomes in experimental models of delayed-onset muscle soreness and nerve growth factor injection of the masticatory muscles

AU - Zhang, Yuanxiu

AU - Exposto, Fernando G.

AU - Grigoriadis, Anastasios

AU - Lobbezoo, Frank

AU - Koutris, Michail

AU - Zhang, Jinglu

AU - Wang, Lin

AU - Svensson, Peter

N1 - Funding Information: This work was funded by the Section of Orofacial Pain and Jaw Function, Department of Dentistry, Aarhus University, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, 2018-87) and the Chinese Government Scholarship Fund from China Scholarship Council (201708320348). The authors thank all staff of the Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University for their selfless help. They would also like to thank Bente Haugsted for help with preparing the NGF injections, Akiko Shimada for providing the chewing gum, and Karina H. Bendixen for her contribution to the study. The authors declare no conflicts of interest. P.S., M.K., F.G.E., Y.Z.: contributed to study design and acquisition of data; F.G.E., Y.Z.: drafted the article. All authors revised the article for important intellectual concent. Publisher Copyright: © 2020 by Quintessence Publishing Co Inc.

PY - 2020/10

Y1 - 2020/10

N2 - To compare two pain models of myalgic TMD, delayed-onset muscle soreness (DOMS) and injections of nerve growth factor (NGF), in terms of pain-related and motor function outcomes, as well as activity-related temporal summation. Methods: Fifty age- and gender-matched healthy participants were recruited and randomized into one of three groups: to a repeated eccentric contraction task to cause DOMS (n = 20), to receive NGF injections into the masseter muscle (n = 20), or to a control group (n = 10). Mechanical sensitivity of masticatory muscles, chewing parameters, jaw function limitation, maximum bite force, and activity-related temporal summation were assessed at baseline and at days 1, 2, and 7 following the intervention. Results: Compared to baseline, both model groups showed increased mechanical sensitivity, jaw function limitation, pain on chewing, and decreased chewing efﬁciency, lasting longer in the NGF group than in the DOMS group (P <.05). Furthermore, also compared to baseline, the NGF group showed increased pain on maximum bite and decreased pain-free maximum opening (P <.05). No increases in activity-related temporal summation were shown for any of the model groups when compared to baseline or the control group (P >.05). Conclusion: Both models produced similar pain- related outcomes, with the NGF model having a longer effect. Furthermore, the NGF model showed a more substantial effect on motor function, which was not seen for the DOMS model. Finally, neither of the models were able to provoke activity-related temporal summation of pain. J Oral Facial Pain Headache 2020;34:311–322. doi: 10.11607/ofph.2623

AB - To compare two pain models of myalgic TMD, delayed-onset muscle soreness (DOMS) and injections of nerve growth factor (NGF), in terms of pain-related and motor function outcomes, as well as activity-related temporal summation. Methods: Fifty age- and gender-matched healthy participants were recruited and randomized into one of three groups: to a repeated eccentric contraction task to cause DOMS (n = 20), to receive NGF injections into the masseter muscle (n = 20), or to a control group (n = 10). Mechanical sensitivity of masticatory muscles, chewing parameters, jaw function limitation, maximum bite force, and activity-related temporal summation were assessed at baseline and at days 1, 2, and 7 following the intervention. Results: Compared to baseline, both model groups showed increased mechanical sensitivity, jaw function limitation, pain on chewing, and decreased chewing efﬁciency, lasting longer in the NGF group than in the DOMS group (P <.05). Furthermore, also compared to baseline, the NGF group showed increased pain on maximum bite and decreased pain-free maximum opening (P <.05). No increases in activity-related temporal summation were shown for any of the model groups when compared to baseline or the control group (P >.05). Conclusion: Both models produced similar pain- related outcomes, with the NGF model having a longer effect. Furthermore, the NGF model showed a more substantial effect on motor function, which was not seen for the DOMS model. Finally, neither of the models were able to provoke activity-related temporal summation of pain. J Oral Facial Pain Headache 2020;34:311–322. doi: 10.11607/ofph.2623

KW - experimental pain

KW - mechanical sensitivity

KW - myalgia

KW - temporal summation

KW - trigeminal motor physiology

UR - http://www.scopus.com/inward/record.url?scp=85097514859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85097514859&partnerID=8YFLogxK

U2 - 10.11607/ofph.2623

DO - 10.11607/ofph.2623

M3 - Article

C2 - 33290437

SN - 2333-0384

VL - 34

SP - 311

EP - 322

JO - Journal of oral & facial pain and headache

JF - Journal of oral & facial pain and headache

IS - 4

ER -

Comparison of pain-generated functional outcomes in experimental models of delayed-onset muscle soreness and nerve growth factor injection of the masticatory muscles

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this