Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing

Stefan O Mueller, Wolfgang Dekant, Paul Jennings, Emanuela Testai, Frederic Y Bois

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

This special issue of Toxicology in Vitro is dedicated to disseminating the results of the EU-funded collaborative project "Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics" (Predict-IV; Grant 202222). The project's overall aim was to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in silico modeling, in a rapid and cost effective manner. This overview introduces the scope and overall achievements of Predict-IV.

Original languageEnglish
Pages (from-to)4-6
Number of pages3
JournalToxicology in Vitro
Volume30
Issue number1 Pt A
DOIs
Publication statusPublished - 25 Dec 2015

Keywords

  • Animals
  • Cell Culture Techniques
  • Drug Discovery
  • Drug-Related Side Effects and Adverse Reactions
  • European Union
  • Humans
  • Models, Biological
  • No-Observed-Adverse-Effect Level
  • Pharmaceutical Preparations
  • Systems Biology
  • Toxicity Tests
  • Toxicology
  • Introductory Journal Article
  • Research Support, Non-U.S. Gov't

Fingerprint

Dive into the research topics of 'Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing'. Together they form a unique fingerprint.

Cite this