Comprehensive two-dimensional gas chromatograpy with time-of-flight mass spectrometric detection applied to the determination of pesticides in food extracts

J. Dalluge, M.J. van Rijn, J. Beens, R.J.J. Vreuls, U.A.T. Brinkman

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The separation provided by conventional gas chromatography (1D-GC) can be significantly enhanced by using comprehensive two-dimensional GC (GC×GC) instead. Combination with mass spectrometric detection is desirable for unambiguous confirmation of target compounds and the provisional identification of unknowns. A GC×GC system using a cryogenic modulator was coupled to a time-of-flight mass spectrometric (TOF MS) detector. With the determination of pesticides in vegetable extracts as an example, it was demonstrated that GC×GC improves the separation dramatically. All 58 pesticides of interest could be identified using their full-scan mass spectra, which was not possible when using 1D-GC-TOF MS. In addition, the high scan speed of the TOF MS allowed the deconvolution of compounds partly co-eluting in GC×GC. © 2002 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)207-217
JournalJournal of Chromatography A
Volume965
Issue number1-2
DOIs
Publication statusPublished - 2002

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