Confounding factors from inducible systems for spatiotemporal gene expression regulation

Rob C.I. Wüst, Riekelt H. Houtkooper, Johan Auwerx

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect whole-organism physiology and function due to off-target effects. We highlight some of these adverse effects, including whole-body endocrinology and disturbances in the gut microbiome and in mitochondrial and metabolic function.

Original languageEnglish
Article numbere202003031
Pages (from-to)1-4
Number of pages4
JournalThe Journal of cell biology
Volume219
Issue number7
Early online date19 May 2020
DOIs
Publication statusPublished - 6 Jul 2020

Fingerprint Dive into the research topics of 'Confounding factors from inducible systems for spatiotemporal gene expression regulation'. Together they form a unique fingerprint.

Cite this