Abstract
Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect whole-organism physiology and function due to off-target effects. We highlight some of these adverse effects, including whole-body endocrinology and disturbances in the gut microbiome and in mitochondrial and metabolic function.
| Original language | English |
|---|---|
| Article number | e202003031 |
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | The Journal of cell biology |
| Volume | 219 |
| Issue number | 7 |
| Early online date | 19 May 2020 |
| DOIs | |
| Publication status | Published - 6 Jul 2020 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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