Connecting brain and behavior in clinical neuroscience: A network approach

Tessa F. Blanken*, Joe Bathelt, Marie K. Deserno, Lily Voge, Denny Borsboom, Linda Douw

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

In recent years, there has been an increase in applications of network science in many different fields. In clinical neuroscience and psychopathology, the developments and applications of network science have occurred mostly simultaneously, but without much collaboration between the two fields. The promise of integrating these network applications lies in a united framework to tackle one of the fundamental questions of our time: how to understand the link between brain and behavior. In the current overview, we bridge this gap by introducing conventions in both fields, highlighting similarities, and creating a common language that enables the exploitation of synergies. We provide research examples in autism research, as it accurately represents research lines in both network neuroscience and psychological networks. We integrate brain and behavior not only semantically, but also practically, by showcasing three methodological avenues that allow to combine networks of brain and behavioral data. As such, the current paper offers a stepping stone to further develop multi-modal networks and to integrate brain and behavior.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalNeuroscience and Biobehavioral Reviews
Volume130
DOIs
Publication statusPublished - Nov 2021

Bibliographical note

Funding Information:
This work was supported by a BIAL Foundation grant 284/20 awarded to TF Blanken and an NWO Vidi grant 198.015 awarded to L Douw.

Publisher Copyright:
© 2021 The Author(s)

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Funding

This work was supported by a BIAL Foundation grant 284/20 awarded to TF Blanken and an NWO Vidi grant 198.015 awarded to L Douw.

FundersFunder number
Horizon 2020 Framework Programme647209
Nederlandse Organisatie voor Wetenschappelijk Onderzoek198.015
Fundação Bial284/20

    Keywords

    • Behavior
    • Brain
    • Clinical neuroscience
    • Graph theory
    • Network science
    • Psychopathology

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