TY - JOUR
T1 - Constitutive signaling of the Human Cytomegalovirus-encoded Chemokine receptor US28
AU - Casarosa, P
AU - Bakker, R.A.
AU - Verzijl, D.
AU - Navis, M.
AU - Timmerman, H.
AU - Leurs, R.
AU - Smit, M.J.
PY - 2001
Y1 - 2001
N2 - Previously it was shown that the HHV-8-encoded chemokine receptor ORF74 shows considerable agonist-independent, constitutive activity giving rise to oncogenic transformation (Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M. C., and Cesarman, E. (1997) Nature 385, 347-350). In this study we report that a second viral-encoded chemokine receptor, the human cytomegalovirus-encoded US28, also efficiently signals in an agonist-independent manner. Transient expression of US28 in COS-7 cells leads to the constitutive activation of phospholipase C and NF-κB signaling via G
AB - Previously it was shown that the HHV-8-encoded chemokine receptor ORF74 shows considerable agonist-independent, constitutive activity giving rise to oncogenic transformation (Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M. C., and Cesarman, E. (1997) Nature 385, 347-350). In this study we report that a second viral-encoded chemokine receptor, the human cytomegalovirus-encoded US28, also efficiently signals in an agonist-independent manner. Transient expression of US28 in COS-7 cells leads to the constitutive activation of phospholipase C and NF-κB signaling via G
U2 - 10.1074/jbc.M008965200
DO - 10.1074/jbc.M008965200
M3 - Article
SN - 0021-9258
VL - 276
SP - 1133
EP - 1137
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
ER -