Constitutive signaling of the Human Cytomegalovirus-encoded Chemokine receptor US28

P Casarosa, R.A. Bakker, D. Verzijl, M. Navis, H. Timmerman, R. Leurs, M.J. Smit

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Abstract

Previously it was shown that the HHV-8-encoded chemokine receptor ORF74 shows considerable agonist-independent, constitutive activity giving rise to oncogenic transformation (Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M. C., and Cesarman, E. (1997) Nature 385, 347-350). In this study we report that a second viral-encoded chemokine receptor, the human cytomegalovirus-encoded US28, also efficiently signals in an agonist-independent manner. Transient expression of US28 in COS-7 cells leads to the constitutive activation of phospholipase C and NF-κB signaling via G
Original languageEnglish
Pages (from-to)1133-1137
JournalJournal of Biological Chemistry
Volume276
DOIs
Publication statusPublished - 2001

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