Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors

R.A. Bakker; A. Jongejan; K. Sansuk; U. Hacksell; H. Timmerman; M.R. Brann; D.M. Weiner; L.M. Pardo; R. Leurs

doi:10.1124/mol.107.038547

Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors

R.A. Bakker, A. Jongejan, K. Sansuk, U. Hacksell, H. Timmerman, M.R. Brann, D.M. Weiner, L.M. Pardo, R. Leurs

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The aim of this study was to create and characterize constitutively active mutant (CAM) histamine H

Original language	English
Pages (from-to)	94-103
Journal	Molecular Pharmacology
Volume	73
Issue number	1
DOIs	https://doi.org/10.1124/mol.107.038547
Publication status	Published - 2008

Access to Document

10.1124/mol.107.038547

Handle.net

Persistent link

Cite this

Bakker, R. A., Jongejan, A., Sansuk, K., Hacksell, U., Timmerman, H., Brann, M. R., Weiner, D. M., Pardo, L. M., & Leurs, R. (2008). Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors. Molecular Pharmacology, 73(1), 94-103. https://doi.org/10.1124/mol.107.038547

@article{d0dc2573657b4224a703ff2c02dfbee8,

title = "Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors",

abstract = "The aim of this study was to create and characterize constitutively active mutant (CAM) histamine H",

author = "R.A. Bakker and A. Jongejan and K. Sansuk and U. Hacksell and H. Timmerman and M.R. Brann and D.M. Weiner and L.M. Pardo and R. Leurs",

year = "2008",

doi = "10.1124/mol.107.038547",

language = "English",

volume = "73",

pages = "94--103",

journal = "Molecular pharmacology",

issn = "0026-895X",

publisher = "American Society for Pharmacology and Experimental Therapeutics",

number = "1",

}

Bakker, RA, Jongejan, A, Sansuk, K, Hacksell, U, Timmerman, H, Brann, MR, Weiner, DM, Pardo, LM & Leurs, R 2008, 'Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors', Molecular Pharmacology, vol. 73, no. 1, pp. 94-103. https://doi.org/10.1124/mol.107.038547

TY - JOUR

T1 - Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors

AU - Bakker, R.A.

AU - Jongejan, A.

AU - Sansuk, K.

AU - Hacksell, U.

AU - Timmerman, H.

AU - Brann, M.R.

AU - Weiner, D.M.

AU - Pardo, L.M.

AU - Leurs, R.

PY - 2008

Y1 - 2008

N2 - The aim of this study was to create and characterize constitutively active mutant (CAM) histamine H

AB - The aim of this study was to create and characterize constitutively active mutant (CAM) histamine H

U2 - 10.1124/mol.107.038547

DO - 10.1124/mol.107.038547

M3 - Article

SN - 0026-895X

VL - 73

SP - 94

EP - 103

JO - Molecular pharmacology

JF - Molecular pharmacology

IS - 1

ER -

Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors

Abstract

Access to Document

Handle.net

Fingerprint

Cite this