Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course

Camiel M. van der Laan, Steve G.A. van de Weijer, Hill F. Ip, Christel Middeldorp, Fiona A. Hagenbeek, Eveline De Zeeuw, Toos C.E.M. Van Beijsterveldt, Meike Bartels, René Pool, Jouke Jan Hottenga, Michel G. Nivard, Dorret I. Boomsma, on behalf of the ACTION Consortium

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12–70 years, Australia: 16–73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a ‘rolling weights’ model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41–70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.

Original languageEnglish
Pages (from-to)592-606
Number of pages15
JournalBehavior Genetics
Volume51
Issue number5
Early online date14 Aug 2021
DOIs
Publication statusPublished - Sep 2021

Bibliographical note

Funding Information:
CvdL was supported by the Amsterdam Law and Behavior Institute (A-LAB; Vrije Universtiteit, Amsterdam). SvdW was suppported by NWO-grant 451-16-014. Data collection was made possible by multiple grants from The Netherlands Organization for Scientific Research (NWO): 575-25-006, 480-04-004, 904-61-090, 904-61-193, 400-05-717, 311-60008, SPI 56-464-14192 and the Avera Institute for Human Genetics. We gratefully acknowledge grant NWO 480-15-001/674: Netherlands Twin Registry Repository: researching the interplay between genome and environment. MGN is supported by ZonMw grant: ‘Genetics as a research tool: a natural experiment to elucidate the causal effects of social mobility on health’ (pnr: 531003014) and ZonMw project: ‘Can sex- and gender-specific gene expression and epigenetics explain sex-differences in disease prevalence and etiology?’ (pnr: 849200011). Data collection in the Australian sample was made possible by multiple grants from NHMRC (APP1069141) and the John Templeton Foundation (Genetics and Human Agency Project). We also thank David Smyth and Scott Gordon for IT support and Richard Parker as project manager. The 16UP study was supported by the Young and Well Cooperative Research Centre, which was established and funded under the Australian Government’s Cooperative Research Centres Program. The Prospective Imaging Study of Aging: Genes, Brain and Behaviour (PISA) is funded by a National Health and Medical Research Council (NHMRC) Boosting Dementia Research Initiative—Team Grant (APP1095227). Genome-wide SNP genotyping data for PISA participants is sourced from several genetic epidemiology studies led by NGM (with colleagues and collaborators) at QIMR Berghofer and elsewhere over the past 40 years. Principal sources of funding for these early studies were from grants to NGM from Australian NHMRC and to Andrew Heath and Pam Madden (Washington University, St Louis) from NIH (mainly NIAAA and NIDA) and we gratefully acknowledge these contributions. JJM was supported by a QIMR Berghofer International PhD Scholarship. LC-C was supported by a QIMR Berghofer Research Fellowship. SEM and NGM were funded by NHMRC investigator grants (APP1172917 and APP1172990).

Publisher Copyright:
© 2021, The Author(s).

Keywords

  • Aggression
  • Aggressive behavior
  • Development
  • Life-course
  • Polygenic score
  • Rolling weights

Fingerprint

Dive into the research topics of 'Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course'. Together they form a unique fingerprint.

Cite this