Continuous Synthesis of Tri- and Tetrasubstituted Imidazoles via a Multicomponent Reaction under Microreactor Conditions

D.R.J. Acke; R.V.A. Orru; C.V. Stevens

doi:10.1002/qsar.200540194

Continuous Synthesis of Tri- and Tetrasubstituted Imidazoles via a Multicomponent Reaction under Microreactor Conditions

D.R.J. Acke
, R.V.A. Orru
, C.V. Stevens

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Using a modified Radziszewski reaction, a procedure has been optimized for the generation of tri- and tetrasubstituted imidazoles via microreactor technology. Optimization included the search for a suitable solvent mixture, temperature and reaction time. Finally, the generality of the optimized reaction was tested using different starting materials. It was possible to create a variety of tri- and tetrasubstituted imidazoles in moderate to good yields via a continuous procedure. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	474
Journal	QSAR and Combinatorial Science
Volume	25
DOIs	https://doi.org/10.1002/qsar.200540194
Publication status	Published - 2006

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10.1002/qsar.200540194

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abstract = "Using a modified Radziszewski reaction, a procedure has been optimized for the generation of tri- and tetrasubstituted imidazoles via microreactor technology. Optimization included the search for a suitable solvent mixture, temperature and reaction time. Finally, the generality of the optimized reaction was tested using different starting materials. It was possible to create a variety of tri- and tetrasubstituted imidazoles in moderate to good yields via a continuous procedure. {\textcopyright} 2006 Wiley-VCH Verlag GmbH \& Co. KGaA.",

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AB - Using a modified Radziszewski reaction, a procedure has been optimized for the generation of tri- and tetrasubstituted imidazoles via microreactor technology. Optimization included the search for a suitable solvent mixture, temperature and reaction time. Finally, the generality of the optimized reaction was tested using different starting materials. It was possible to create a variety of tri- and tetrasubstituted imidazoles in moderate to good yields via a continuous procedure. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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Continuous Synthesis of Tri- and Tetrasubstituted Imidazoles via a Multicomponent Reaction under Microreactor Conditions

Abstract

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