Cortical morphology as a shared neurobiological substrate of attention-deficit/hyperactivity symptoms and executive functioning: a population-based pediatric neuroimaging study

S.E. Mous, T. White, R.L. Muetzel, H. El Marroun, J. Rijlaarsdam, J.C. Polderman, V.W. Jaddoe, F.C. Verhulst, D. Posthuma, H. Tiemeier

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND: Attention-deficit/hyperactivity symptoms have repeatedly been associated with poor cognitive functioning. Genetic studies have demonstrated a shared etiology of attention-deficit/hyperactivity disorder (ADHD) and cognitive ability, suggesting a common underlying neurobiology of ADHD and cognition. Further, neuroimaging studies suggest that altered cortical development is related to ADHD. In a large population-based sample we investigated whether cortical morphology, as a potential neurobiological substrate, underlies the association between attention-deficit/hyperactivity symptoms and cognitive problems.

METHODS: The sample consisted of school-aged children with data on attention-deficit/hyperactivity symptoms, cognitive functioning and structural imaging. First, we investigated the association between attention-deficit/ hyperactivity symptoms and different domains of cognition. Next, we identified cortical correlates of attention-deficit/hyperactivity symptoms and related cognitive domains. Finally, we studied the role of cortical thickness and gyrification in the behaviour-cognition associations.

RESULTS: We included 776 children in our analyses. We found that attention-deficit/hyperactivity symptoms were associated specifically with problems in attention and executive functioning (EF; b = -0.041, 95% confidence interval [CI] -0.07 to -0.01, p = 0.004). Cortical thickness and gyrification were associated with both attention-deficit/hyperactivity symptoms and EF in brain regions that have been previously implicated in ADHD. This partly explained the association between attention-deficit/hyperactivity symptoms and EF (bindirect = -0.008, bias-corrected 95% CI -0.018 to -0.001).

LIMITATIONS: The nature of our study did not allow us to draw inferences regarding temporal associations; longitudinal studies are needed for clarification.

CONCLUSION: In a large, population-based sample of children, we identified a shared cortical morphology underlying attention-deficit/hyperactivity symptoms and EF.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalJournal of Psychiatry and Neuroscience
Volume42
Issue number2
DOIs
Publication statusPublished - Mar 2017

Keywords

  • Attention
  • Attention Deficit Disorder with Hyperactivity
  • Brain
  • Child
  • Cognition
  • Cohort Studies
  • Executive Function
  • Female
  • Humans
  • Journal Article
  • Male
  • Neuroimaging
  • Neuropsychological Tests
  • Organ Size
  • Regression Analysis
  • Sex Characteristics

Fingerprint

Dive into the research topics of 'Cortical morphology as a shared neurobiological substrate of attention-deficit/hyperactivity symptoms and executive functioning: a population-based pediatric neuroimaging study'. Together they form a unique fingerprint.

Cite this