Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers

Robert Egger, Rajeevan T. Narayanan, Jason M. Guest, Arco Bast, Daniel Udvary, Luis F. Messore, Suman Das, Christiaan P.J. de Kock, Marcel Oberlaender

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Here, we report the origins of the PTs’ ability to respond to a broad range of stimuli with onset latencies that rival or even precede those of their intracortical input neurons. We find that neurons with extensive horizontally projecting axons cluster around the deep-layer terminal fields of primary thalamocortical axons. The strategic location of these corticocortical neurons results in high convergence of thalamocortical inputs, which drive reliable sensory-evoked responses that precede those in other excitatory cell types. The resultant fast and horizontal stream of excitation provides PTs throughout the cortical area with input that acts to amplify additional inputs from thalamocortical and other intracortical populations. The fast onsets and broadly tuned characteristics of PT responses hence reflect a gating mechanism in the deep layers, which assures that sensory-evoked input can be reliably transformed into cortical output.

Original languageEnglish
Pages (from-to)122-137.e8
Number of pages24
JournalNeuron
Volume105
Issue number1
Early online date26 Nov 2019
DOIs
Publication statusPublished - 8 Jan 2020

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Neurons
Axons
Pyramidal Tracts
Pyramidal Cells
Neocortex
Population

Keywords

  • barrel cortex
  • corticocortical neurons
  • in silico
  • pyramidal tract neurons
  • synchrony

Cite this

Egger, R., Narayanan, R. T., Guest, J. M., Bast, A., Udvary, D., Messore, L. F., ... Oberlaender, M. (2020). Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers. Neuron, 105(1), 122-137.e8. https://doi.org/10.1016/j.neuron.2019.10.011
Egger, Robert ; Narayanan, Rajeevan T. ; Guest, Jason M. ; Bast, Arco ; Udvary, Daniel ; Messore, Luis F. ; Das, Suman ; de Kock, Christiaan P.J. ; Oberlaender, Marcel. / Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers. In: Neuron. 2020 ; Vol. 105, No. 1. pp. 122-137.e8.
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Egger, R, Narayanan, RT, Guest, JM, Bast, A, Udvary, D, Messore, LF, Das, S, de Kock, CPJ & Oberlaender, M 2020, 'Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers' Neuron, vol. 105, no. 1, pp. 122-137.e8. https://doi.org/10.1016/j.neuron.2019.10.011

Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers. / Egger, Robert; Narayanan, Rajeevan T.; Guest, Jason M.; Bast, Arco; Udvary, Daniel; Messore, Luis F.; Das, Suman; de Kock, Christiaan P.J.; Oberlaender, Marcel.

In: Neuron, Vol. 105, No. 1, 08.01.2020, p. 122-137.e8.

Research output: Contribution to JournalArticleAcademicpeer-review

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Egger R, Narayanan RT, Guest JM, Bast A, Udvary D, Messore LF et al. Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers. Neuron. 2020 Jan 8;105(1):122-137.e8. https://doi.org/10.1016/j.neuron.2019.10.011